propranolol vs thioridazine
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Side-by-side comparison of propranolol and thioridazine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Reduced cytochrome P450 2D6 isozyme activity, drugs which inhibit this isozyme (e.g., fluoxetine and paroxetine), and certain other drugs (e.g., fluvoxamine, propranolol, and pindolol) appear to appreciably inhibit the metabolism of thioridazine. Propranolol Concurrent administration of propranolol (100 mg to 800 mg daily) has been reported to produce increases in plasma levels of thioridazine (approximately 50% to 400%) and its metabolites (approximately 80% to 300%). Propranolol and thioridazine should not be coadministered.
Inderal
Mellaril
Propranolol is a medicine that can help with high blood pressure, chest pain, and other conditions. It works by blocking the effects of certain natural chemicals in your body, like adrenaline, that affect the heart and blood vessels.
Thioridazine is a medicine used to treat schizophrenia. It is only used when other antipsychotic medicines have not worked well enough.
Propranolol tablets can treat high blood pressure. It can be used alone or with other medicines. Propranolol can also help with chest pain (angina), control fast heart rate with atrial fibrillation, improve survival after a heart attack, prevent migraine headaches, and reduce tremors. It can also help with symptoms of some tumors.
Thioridazine is used to manage schizophrenia in adults and children. You should only use this medicine if other antipsychotic medicines have not worked for you. This is because thioridazine can cause serious heart problems.
Propranolol is a beta-blocker. It works by blocking the effects of adrenaline on your heart and blood vessels. This helps to slow down your heart rate and lower your blood pressure.
Thioridazine affects the balance of certain chemicals in the brain. These chemicals, like dopamine, can affect mood and behavior. By changing the balance, thioridazine helps to reduce symptoms of schizophrenia.
- • Tiredness
- • Dizziness
- • Nausea
- • Vomiting
- • Diarrhea
- • Drowsiness
- • Dry mouth
- • Blurred vision
- • Constipation
- • Nausea
- Nausea 4,279
- Headache 3,785
- Fatigue 3,752
- Diarrhoea 3,119
- Dizziness 3,102
- Weight Increased 8
- Dyspnoea 7
- Dystonia 6
- Hyperglycaemia 6
- Hypoxia 6
Propranolol is contraindicated in people with cardiogenic shock, very slow heart rate, asthma, or those who are allergic to it.
Thioridazine can cause a life-threatening heart rhythm problem called Torsades de pointes, which can lead to sudden death. Because of this risk, only use thioridazine if other antipsychotic medicines have not worked. Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death.
Tell your doctor if you are pregnant or plan to become pregnant. Propranolol may affect your baby. Talk to your doctor about the risks and benefits of taking propranolol during pregnancy or while breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if thioridazine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking thioridazine during pregnancy and breastfeeding.
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How to Read This propranolol vs thioridazine Comparison
propranolol is classified in the Non-Selective Beta-Blocker drug class, while thioridazine sits within the Typical Antipsychotic (Phenothiazine) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, propranolol has 18,037 submissions while thioridazine has 33. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to propranolol slows down how fast your body can break down thioridazine. this causes the level of thioridazine in your blood to rise to a much higher level than normal.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for propranolol or thioridazine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.