isavuconazonium vs posaconazole
Side-by-side comparison of isavuconazonium and posaconazole Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Cresemba
Noxafil
Cresemba is an antifungal medicine. It is used to treat serious fungal infections in adults and children.
Posaconazole is an antifungal medicine. It helps prevent certain fungal infections in people with weakened immune systems.
Cresemba treats invasive aspergillosis and invasive mucormycosis. These are serious infections caused by different types of fungi. Cresemba is available as an injection for those 1 year and older. Cresemba capsules are for those 6 years and older who weigh at least 35 pounds.
Posaconazole prevents Aspergillus and Candida infections. You may need this medicine if you have a high risk of getting these infections. This often includes people who had a stem cell transplant or have certain blood cancers and are on chemotherapy.
Cresemba belongs to a class of drugs called azole antifungals. It works by stopping the growth of the fungi. This helps your body fight off the infection.
Posaconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. This helps your body fight off the infection.
- • Nausea
- • Vomiting
- • Diarrhea
- • Headache
- • Changes in liver tests
- • Diarrhea
- • Nausea
- • Fever
- • Vomiting
- • Headache
- Using the medicine for a condition it is not approved for 926
- Death 310
- Feeling sick to your stomach 143
- Fever with low white blood cell count 135
- Medicine not working 125
- Using the medicine for a condition it is not approved for 1,542
- The medicine is not working 1,434
- Fever with low white blood cell count 1,018
- The medicine is interacting with another medicine 930
- Death 928
Cresemba can cause serious liver problems. Your doctor will check your liver function before and during treatment. Cresemba can also cause allergic reactions. Tell your doctor right away if you have any signs of a reaction, like trouble breathing or skin rash. Cresemba can harm an unborn baby. Use birth control while taking this medicine.
Posaconazole can interact with many other medicines. It can cause heart rhythm problems (QT prolongation). It can also cause liver problems. Tell your doctor about all the medicines you take.
Cresemba can harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Do not breastfeed while taking Cresemba.
Posaconazole may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if posaconazole passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This isavuconazonium vs posaconazole Comparison
isavuconazonium is classified in the Azole Antifungal drug class, while posaconazole sits within the Azole Antifungal class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, isavuconazonium has 1,639 submissions while posaconazole has 5,852. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between isavuconazonium and posaconazole — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.