aripiprazole vs olanzapine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of aripiprazole and olanzapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Abilify
Zyprexa
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems. It can help to improve your mood, thinking, and behavior.
Olanzapine is a medicine used to treat certain mental disorders. It helps to balance chemicals in the brain to improve mood and behavior.
Aripiprazole is used to treat schizophrenia in adults and teens. It also treats irritability in children with autism. Additionally, it can treat Tourette's disorder.
Olanzapine is used to treat schizophrenia in adults and teens (13-17). It also treats manic or mixed episodes of bipolar I disorder in adults and teens (13-17). In adults, it can be used with other medicines to treat bipolar depression.
Aripiprazole works by affecting the levels of certain chemicals in the brain. These chemicals, like dopamine and serotonin, can affect mood and behavior. By balancing these chemicals, aripiprazole helps to reduce symptoms of mental health conditions.
Olanzapine is an atypical antipsychotic. It works by affecting the levels of certain chemicals in your brain. These chemicals include dopamine and serotonin, which can help improve mood, thinking, and behavior.
- • Nausea
- • Vomiting
- • Constipation
- • Headache
- • Dizziness
- • Dizziness
- • Weight gain
- • Increased appetite
- • Dry mouth
- • Constipation
- Weight Increased 7,698
- Anxiety 4,993
- Fatigue 4,188
- Suicidal Ideation 3,991
- Depression 3,950
- Weight Increased 6,722
- Diabetes Mellitus 5,388
- Drug Interaction 4,048
- Toxicity To Various Agents 3,966
- Somnolence 3,839
Aripiprazole may increase the risk of death in elderly patients who have psychosis related to dementia. It is not approved for this use. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Watch closely for worsening mood or suicidal thoughts.
Olanzapine can increase the risk of death in older adults with dementia-related psychosis. Olanzapine is not approved to treat this condition. When using olanzapine with fluoxetine, read the Symbyax label for more warnings.
If you are pregnant or plan to become pregnant, talk to your doctor. Aripiprazole may cause withdrawal symptoms or other problems in newborns if taken during the third trimester. There is a pregnancy registry for women who take aripiprazole during pregnancy.
If you take olanzapine during the third trimester of pregnancy, your baby may have withdrawal symptoms after birth. There is a pregnancy registry to monitor outcomes in women who take atypical antipsychotics during pregnancy. Talk to your doctor.
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How to Read This aripiprazole vs olanzapine Comparison
aripiprazole is classified in the Atypical Antipsychotic drug class, while olanzapine sits within the Atypical Antipsychotic class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aripiprazole has 24,820 submissions while olanzapine has 23,963. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for aripiprazole or olanzapine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.