lisinopril vs trandolapril
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of lisinopril and trandolapril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Prinivil, Zestril
Mavik
No summary available.
Trandolapril (Mavik) is a medicine that lowers blood pressure. It can also help people who have had a heart attack and have a weak heart.
Information not available.
Trandolapril is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. It is also used in people who have had a heart attack and have a weak heart (left ventricular dysfunction) or heart failure.
Information not available.
Trandolapril belongs to a class of drugs called ACE inhibitors. It works by blocking a substance in your body that tightens blood vessels. This helps your blood vessels relax and lowers your blood pressure.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- • Cough
- • Dizziness
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
- Dyspnoea 137
- Fatigue 119
- Dizziness 108
- Diarrhoea 99
- Cough 97
No specific warnings noted.
If you become pregnant, stop taking trandolapril right away. This medicine can harm or cause death to your unborn baby.
No pregnancy information available.
Do not take trandolapril if you are pregnant. It can cause serious harm to your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
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How to Read This lisinopril vs trandolapril Comparison
lisinopril is classified in the ACE Inhibitor drug class, while trandolapril sits within the ACE Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lisinopril has 81,066 submissions while trandolapril has 560. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for lisinopril or trandolapril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.