lisinopril vs perindopril
Side-by-side comparison of lisinopril and perindopril Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Prinivil, Zestril
Aceon
Lisinopril and hydrochlorothiazide is a drug that lowers blood pressure. It contains two medicines that work together to help your heart.
Perindopril (Aceon) is a drug that lowers blood pressure. It can also help reduce the risk of heart problems in people with stable coronary artery disease.
This medicine treats high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks. You should also manage cholesterol, diabetes, and quit smoking to improve your heart health.
Perindopril treats high blood pressure (hypertension). It can be used alone or with other blood pressure medicines. Perindopril also helps lower the risk of heart-related death or heart attack in people who have stable coronary artery disease. It can be used with other treatments for coronary artery disease.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. Together, they lower blood pressure more effectively.
Perindopril belongs to a class of drugs called ACE inhibitors. It works by relaxing your blood vessels, which lowers blood pressure. This makes it easier for your heart to pump blood.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- • Cough
- • Dizziness
- • Back pain
- Feeling tired 19,347
- Feeling sick to your stomach 17,995
- The medicine is not working 17,182
- Loose stools 16,772
- Difficulty breathing 13,649
No adverse event reports.
This drug can harm your unborn baby, even causing death. Stop taking this medicine as soon as you know you are pregnant.
If you become pregnant, stop taking perindopril right away. This medicine can cause serious harm or death to an unborn baby.
Do not take this medicine if you are pregnant. It can cause serious harm or death to your unborn baby. Talk to your doctor about safe alternatives if you are breastfeeding.
Do not take perindopril if you are pregnant. It can cause harm to your unborn baby, especially during the second and third trimesters. It is not known if perindopril passes into breast milk, so talk to your doctor before breastfeeding.
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How to Read This lisinopril vs perindopril Comparison
lisinopril is classified in the ACE Inhibitor drug class, while perindopril sits within the ACE Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lisinopril has 84,945 submissions while perindopril has 0. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between lisinopril and perindopril — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.