lisinopril vs perindopril
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of lisinopril and perindopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Prinivil, Zestril
Aceon
No summary available.
Perindopril (Aceon) is a drug that lowers blood pressure. It can also help reduce the risk of heart problems in people with stable coronary artery disease.
Information not available.
Perindopril treats high blood pressure (hypertension). It can be used alone or with other blood pressure medicines. Perindopril also helps lower the risk of heart-related death or heart attack in people who have stable coronary artery disease. It can be used with other treatments for coronary artery disease.
Information not available.
Perindopril belongs to a class of drugs called ACE inhibitors. It works by relaxing your blood vessels, which lowers blood pressure. This makes it easier for your heart to pump blood.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- • Cough
- • Dizziness
- • Back pain
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
No adverse event reports.
No specific warnings noted.
If you become pregnant, stop taking perindopril right away. This medicine can cause serious harm or death to an unborn baby.
No pregnancy information available.
Do not take perindopril if you are pregnant. It can cause harm to your unborn baby, especially during the second and third trimesters. It is not known if perindopril passes into breast milk, so talk to your doctor before breastfeeding.
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How to Read This lisinopril vs perindopril Comparison
lisinopril is classified in the ACE Inhibitor drug class, while perindopril sits within the ACE Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lisinopril has 81,066 submissions while perindopril has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for lisinopril or perindopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.