liothyronine vs sertraline
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Side-by-side comparison of liothyronine and sertraline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Administration of sertraline in patients stabilized on liothyronine sodium tablets may result in increased liothyronine sodium tablets requirements.
Cytomel
Zoloft
Liothyronine (Cytomel) is a medicine that replaces a thyroid hormone called T3. It helps your body work properly if you don't make enough thyroid hormone on your own.
Sertraline is a medicine used to treat depression and other mental health conditions. It helps balance chemicals in your brain to improve your mood and reduce anxiety.
This medicine treats hypothyroidism, a condition where your thyroid gland doesn't make enough thyroid hormone. It can also be used with surgery and radiation to manage thyroid cancer. Liothyronine can also be used for thyroid suppression tests to check for mild hyperthyroidism.
Sertraline is used to treat major depressive disorder in adults. This means it can help with ongoing sadness or loss of interest in things. It also treats obsessive-compulsive disorder (OCD), where you have unwanted thoughts or behaviors that you can't control. Sertraline can also treat panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder.
Liothyronine is a synthetic form of the T3 thyroid hormone. It works by increasing thyroid hormone levels in your body. This helps to regulate your body's metabolism and energy levels.
Sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood, and by blocking its reabsorption, sertraline helps improve mood and reduce symptoms of depression and anxiety.
- • Fatigue
- • Increased appetite
- • Weight loss
- • Feeling hot
- • Fever
- • Nausea
- • Diarrhea
- • Headache
- • Insomnia
- • Dizziness
- Headache 859
- Fatigue 816
- Nausea 569
- Dyspnoea 549
- Pain 469
- Nausea 6,466
- Fatigue 5,891
- Diarrhoea 5,216
- Headache 4,927
- Dizziness 4,599
This medicine should not be used for weight loss or to treat obesity. Taking high doses of thyroid hormone for weight loss can cause serious and life-threatening side effects, especially when taken with stimulant medicines.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teens, and young adults. Watch closely for worsening depression, unusual behavior, or thoughts of suicide. Sertraline is not approved for treating depression in children.
Tell your doctor if you are pregnant or plan to become pregnant. Your dose of liothyronine may need to be adjusted during pregnancy. This medicine passes into breast milk, but it is not expected to harm your baby.
Tell your doctor if you are pregnant or plan to become pregnant. Sertraline may affect your baby. Talk to your doctor about the risks and benefits of taking sertraline during pregnancy and breastfeeding.
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How to Read This liothyronine vs sertraline Comparison
liothyronine is classified in the Thyroid Hormone (T3) drug class, while sertraline sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, liothyronine has 3,262 submissions while sertraline has 27,099. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this antidepressant can lower the effectiveness of your thyroid medicine, meaning your body might need a higher dose.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for liothyronine or sertraline.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.