Two medicines, side by side
Lamotrigine vs gabapentin
Lamotrigine and gabapentin are both labeled for seizures and epilepsy. Drugs@FDA records approvals of lamotrigine since 1994 and of gabapentin since 1993. Pharmacies paid $0.0268 per lamotrigine 25 mg tablet and $0.0218 per gabapentin 100 mg capsule (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. Lamotrigine's other strengths are brand-only: $2.86 per mL (Subvenite 10 mg/mL suspension). In FDA's classes, lamotrigine is a mood stabilizer and gabapentin an anti-epileptic agent.
Check it at the source: the lamotrigine FDA label on DailyMed (effective October 10, 2025); the gabapentin FDA label on DailyMed (effective May 12, 2026).
Highlights of the lamotrigine record
Lamotrigine (Lamictal) · label of October 10, 2025
SERIOUS SKIN RASHES LAMICTAL can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 to 17 years) and 0.08% to 0.3% in adults receiving LAMICTAL. One rash-related death was reported in a prospectively followed cohort of 1,983 pediatric patients (aged 2 to 16 years) with epilepsy taking LAMICTAL as adjunctive therapy.
Used for
From the label: indicationsLAMICTAL is indicated for: Epilepsy–adjunctive therapy in patients aged 2 years and older: • partial-onset seizures. • primary generalized tonic-clonic (PGTC) seizures. • generalized seizures of Lennox-Gastaut syndrome. […]
On the market
- Earliest approval on file
- December 27, 1994
- Generic labelers
- 49 labelers
- Pharmacy cost
- $0.0268 per tablet
Supply and safety
- Shortage
- A presentation being discontinued
- Recalls
- 10
Highlights of the gabapentin record
Gabapentin (Neurontin) · label of May 12, 2026
Used for
From the label: indicationsNEURONTIN ® is indicated for: • Management of postherpetic neuralgia in adults • Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization, in adults and pediatric patients 3 years and older with epilepsy NEURONTIN is indicated for: • Postherpetic neuralgia in adults ( 1 ) • Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization, in adults and pediatric patients 3 years and older with epilepsy […]
On the market
- Earliest approval on file
- December 30, 1993
- Generic labelers
- 85 labelers
- Pharmacy cost
- $0.0218 per capsule
Supply and safety
- Shortage
- No current entry
- Recalls
- 22
Source: FDA drug labels via openFDA (Lamotrigine label of October 10, 2025, Gabapentin label of May 12, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do lamotrigine and gabapentin differ on the record?
In FDA's classes, lamotrigine is a mood stabilizer and gabapentin an anti-epileptic agent.
How each works, in its label's words: Lamotrigine, “The precise mechanism(s) by which lamotrigine exerts its anticonvulsant action are unknown.”; Gabapentin, “The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown.”
Only the lamotrigine label carries a boxed warning.
Generics: lamotrigine since 2006; gabapentin since 2003 (Drugs@FDA).
| Lamotrigine | Gabapentin | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Bipolar disorder | Nerve pain and fibromyalgia, Seizures and epilepsy |
| Pharmacologic class | Anti-epileptic Agent, Mood Stabilizer | Anti-epileptic Agent |
| How it works (label) | The precise mechanism(s) by which lamotrigine exerts its anticonvulsant action are unknown. | The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. |
| Half-life (label) | n/a | Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. |
| Earliest approval on file (Drugs@FDA) | December 27, 1994 | December 30, 1993 |
| First generic approved | June 21, 2006 | September 12, 2003 |
| Generic labelers (NDC) | 49 labelers | 85 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.0268 per tablet (Lamotrigine 25 mg tablet) | $0.0218 per capsule (Gabapentin 100 mg capsule) |
| 12-month price change | -12% | +0.9% |
| Boxed warning | Yes | No |
| Shortage now | A presentation being discontinued | No current entry |
| Recalls recorded | 10 | 22 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 130,994 | 362,654 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to lamotrigine
- every medicine labeled for the same conditions