itraconazole vs vilazodone
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Side-by-side comparison of itraconazole and vilazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Sporanox
Viibryd
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Vilazodone (Viibryd) is a medicine used to treat depression in adults. It helps to improve your mood.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Vilazodone is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve these symptoms.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Vilazodone works by affecting certain chemicals in the brain. It increases the amount of serotonin available. Serotonin helps to regulate mood and emotions.
- • Nausea
- • Rash
- • Headache
- • Diarrhea
- • Nausea
- • Vomiting
- • Trouble sleeping (insomnia)
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
- Diarrhoea 808
- Nausea 808
- Anxiety 662
- Insomnia 634
- Headache 565
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely monitor you for worsening depression or suicidal thoughts, especially when you first start taking this medicine or when your dose is changed. Vilazodone is not approved for use in children.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Tell your doctor if you are pregnant or plan to become pregnant. Taking vilazodone late in pregnancy may cause problems for the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can call 1-844-405-6185 to register.
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How to Read This itraconazole vs vilazodone Comparison
itraconazole is classified in the Azole Antifungal drug class, while vilazodone sits within the SSRI / 5-HT1A Partial Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,066 submissions while vilazodone has 3,477. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole blocks the enzymes responsible for clearing vilazodone from your body. this leads to higher levels of the medication in your bloodstream.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for itraconazole or vilazodone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.