itraconazole vs venlafaxine
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Side-by-side comparison of itraconazole and venlafaxine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
SSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions.
Sporanox
Effexor, Effexor XR
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Venlafaxine is a medication used to treat depression. It helps to improve your mood by affecting certain chemicals in the brain.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Venlafaxine is used to treat major depressive disorder. This condition can cause a persistent feeling of sadness or loss of interest in daily activities. It may also help maintain improvement in patients with recurrent depression.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in the brain. These chemicals help regulate mood and can be low in people with depression.
- • Nausea
- • Rash
- • Headache
- • Feeling weak or tired
- • Sweating a lot
- • Feeling sick to your stomach
- • Constipation
- • Loss of appetite
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
- Nausea 4,298
- Toxicity To Various Agents 4,265
- Fatigue 4,198
- Headache 3,740
- Completed Suicide 3,169
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Your doctor will monitor you closely for worsening depression, suicidal thoughts, or unusual changes in behavior. Venlafaxine is not approved for use in children.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
If you are pregnant or breastfeeding, talk to your doctor before taking venlafaxine. Newborns exposed to SNRIs like venlafaxine in the third trimester may have complications requiring hospitalization. Your doctor will carefully consider the risks and benefits of treatment during pregnancy.
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How to Read This itraconazole vs venlafaxine Comparison
itraconazole is classified in the Azole Antifungal drug class, while venlafaxine sits within the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,066 submissions while venlafaxine has 19,670. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole slows down how your body gets rid of venlafaxine, which may increase the amount of antidepressant in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for itraconazole or venlafaxine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.