itraconazole vs nifedipine
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of itraconazole and nifedipine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Sporanox
Procardia, Adalat
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Nifedipine is a calcium channel blocker. It helps to relax blood vessels, which can lower blood pressure and reduce chest pain.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
This medicine treats chest pain (angina) caused by tight blood vessels. It also treats high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Nifedipine blocks calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels. As a result, the heart doesn't have to work as hard, and blood pressure goes down.
- • Nausea
- • Rash
- • Headache
- • Swelling, especially in the legs or ankles
- • Headache
- • Fatigue
- • Dizziness
- • Constipation
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
- Dyspnoea 2,429
- Fatigue 2,304
- Diarrhoea 2,264
- Nausea 2,220
- Headache 1,997
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
In rare cases, nifedipine can cause serious gastrointestinal problems, including obstruction. If you experience severe abdominal pain, vomiting, or inability to pass stool, seek immediate medical attention.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if nifedipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Also Compare, Nearby Drugs
Compare itraconazole with
Compare nifedipine with
How to Read This itraconazole vs nifedipine Comparison
itraconazole is classified in the Azole Antifungal drug class, while nifedipine sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,066 submissions while nifedipine has 11,214. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole prevents your body from processing nifedipine properly, which increases the amount of medicine in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for itraconazole or nifedipine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.