isradipine vs warfarin
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Side-by-side comparison of isradipine and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Warfarin: In a study in healthy volunteers, no clinically relevant pharmacokinetic or pharmacodynamic interaction between isradipine and racemic warfarin was seen when two single oral doses of warfarin (0.7 mg/kg body weight) were administered during 11 days of multiple-dose treatment with 5 mg b.i.d. Neither racemic warfarin nor isradipine binding to plasma proteins in vitro was altered by the addition of the other drug.
DynaCirc
Coumadin, Jantoven
Isradipine is a drug that helps lower high blood pressure. It belongs to a class of drugs called calcium channel blockers.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Isradipine capsules are used to treat high blood pressure. You can take it alone or with a thiazide diuretic (water pill). It may take 2 to 4 weeks to see the full effect.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Isradipine blocks calcium from entering certain cells. This action relaxes blood vessels, which lowers blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Headache
- • Dizziness
- • Swelling in ankles or feet
- • Feeling your heart beat rapidly or irregularly
- • Fatigue
- • Bleeding from any tissue or organ
- Drug Interaction 32
- Dyspnoea 31
- Hypertension 29
- Acute Kidney Injury 26
- Nausea 26
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
If you are taking cimetidine, your doctor should watch you closely for side effects when you start isradipine. If you are taking rifampicin, isradipine may not work as well.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if isradipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking isradipine while breastfeeding.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This isradipine vs warfarin Comparison
isradipine is classified in the Calcium Channel Blocker drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, isradipine has 144 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not appear to change how the body handles or responds to either medication.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for isradipine or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.