fluconazole vs nateglinide
Side-by-side comparison of fluconazole and nateglinide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Table 2: Clinically Significant Drug Interactions with Nateglinide Drugs That May Increase the Blood-Glucose-Lowering Effect of Nateglinide and Susceptibility to Hypoglycemia Drugs: Nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents, anabolic hormones (e.g., methandrostenolone), guanethidine, gymnema sylvestre, glucomannan, thioctic acid, and inhibitors of CYP2C9 (e.g., amiodarone, fluconazole, voriconazole, sulfinpyrazone) or in patients known to be poor metabolizers of CYP2C9 substrates, alcohol.
Recommendation: Your doctor may need to adjust your medication dose or have you monitor your blood sugar more closely for signs of hypoglycemia.
Diflucan
Starlix
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Nateglinide (Starlix) helps control blood sugar in adults with type 2 diabetes. It should be used with diet and exercise.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Nateglinide is used to help lower blood sugar in adults who have type 2 diabetes. You should also follow a diet and exercise plan while taking this medicine. Nateglinide should not be used if you have type 1 diabetes or diabetic ketoacidosis.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Nateglinide helps your pancreas release insulin after you eat. Insulin helps move sugar from your blood into your cells. This lowers your blood sugar levels after meals.
- • Headache
- • Nausea
- • Abdominal pain
- • Upper respiratory infection
- • Back pain
- • Flu symptoms
- • Dizziness
- • Joint pain
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
- High blood sugar 76
- Diarrhea 63
- Difficulty breathing 62
- Tiredness 56
- Feeling sick to your stomach 54
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Nateglinide can cause low blood sugar (hypoglycemia). Take it before meals and skip the dose if you skip the meal to help prevent this. There have been no studies showing that nateglinide lowers your risk of heart or blood vessel problems.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
It is not known if nateglinide can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Nateglinide is not recommended if you are breastfeeding because it may cause low blood sugar in the baby.
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How to Read This fluconazole vs nateglinide Comparison
fluconazole is classified in the Azole Antifungal drug class, while nateglinide sits within the Meglitinide class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,625 submissions while nateglinide has 311. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole stops the body from breaking down nateglinide properly. this can lead to higher levels of the drug in your blood and cause your blood sugar to drop too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluconazole and nateglinide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.