etodolac vs ketoprofen
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of etodolac and ketoprofen. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Lodine
Orudis
Etodolac is a pain reliever and anti-inflammatory medicine. It helps reduce pain, swelling, and stiffness caused by arthritis and other conditions.
Ketoprofen extended-release capsules are a type of NSAID medicine. They help reduce pain and swelling.
Etodolac treats the symptoms of osteoarthritis and rheumatoid arthritis. It can help with pain and swelling in your joints. Etodolac is also used for short-term relief of acute pain.
Ketoprofen extended-release capsules treat the symptoms of rheumatoid arthritis and osteoarthritis. These conditions cause pain, swelling, and stiffness in the joints. This medicine is not for treating sudden, sharp pain.
Etodolac is an NSAID, which stands for Nonsteroidal Anti-Inflammatory Drug. It works by reducing substances in the body that cause pain and inflammation. It can help to reduce fever as well.
Ketoprofen works by reducing substances in the body that cause pain and swelling. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain.
- • Upset stomach
- • Constipation
- • Diarrhea
- • Gas
- • Heartburn
- • Upset stomach
- • Nausea
- • Abdominal pain
- • Diarrhea
- • Constipation
- Pain 350
- Nausea 290
- Arthralgia 284
- Fatigue 272
- Headache 238
- Headache 1,152
- Pain 1,076
- Fatigue 895
- Nausea 746
- Pyrexia 725
NSAIDs like etodolac can increase your risk of heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take etodolac if you are having heart bypass surgery. NSAIDs also increase the risk of serious stomach problems like bleeding and ulcers, which can be fatal. Older adults are at higher risk for these stomach problems.
NSAIDs like ketoprofen can increase the risk of heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take this medicine if you are having heart bypass surgery (CABG). NSAIDs also increase the risk of serious stomach and intestine problems like bleeding and ulcers, which can be fatal. These can occur without warning, and older adults are at higher risk.
Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Etodolac may harm your unborn baby. It is not known if etodolac passes into breast milk.
Talk to your doctor if you are pregnant, may become pregnant, or are breastfeeding. NSAIDs may harm your unborn baby. Ketoprofen may pass into breast milk.
Also Compare, Nearby Drugs
Compare etodolac with
Compare ketoprofen with
How to Read This etodolac vs ketoprofen Comparison
etodolac is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while ketoprofen sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, etodolac has 1,434 submissions while ketoprofen has 4,594. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for etodolac or ketoprofen.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.