eplerenone vs itraconazole
Side-by-side comparison of eplerenone and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Diuretics Eplerenone Finerenone Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: This combination must be avoided during treatment and for two weeks after you stop taking itraconazole.
Inspra
Sporanox
Eplerenone (Inspra) helps you live longer if you have heart failure after a heart attack. It also lowers blood pressure if you have high blood pressure.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Eplerenone is used to help people with heart failure who have had a heart attack live longer. It is also used to treat high blood pressure in adults. Lowering blood pressure helps reduce the risk of strokes and heart attacks.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Eplerenone blocks a hormone called aldosterone in your body. Aldosterone can cause your body to hold onto too much salt and water, which can raise blood pressure and worsen heart failure. By blocking aldosterone, eplerenone helps lower blood pressure and reduce strain on the heart.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • High potassium levels in your blood
- • Increased creatinine levels
- • Nausea
- • Rash
- • Headache
- Shortness of breath 1,083
- Heart failure 939
- Sudden kidney damage 905
- Low blood pressure 859
- Tiredness 658
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
Eplerenone can cause high potassium levels in your blood, which can be dangerous. Your doctor will check your potassium levels before you start taking eplerenone and regularly while you are taking it. People with kidney problems, diabetes, or who take certain other medicines are at higher risk.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
It is not known if eplerenone can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if eplerenone passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking eplerenone.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This eplerenone vs itraconazole Comparison
eplerenone is classified in the Aldosterone Antagonist drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, eplerenone has 4,444 submissions while itraconazole has 3,068. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole prevents your body from processing eplerenone, which can cause the diuretic to reach toxic levels in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between eplerenone and itraconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.