dronedarone vs itraconazole
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of dronedarone and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Antiarrhythmics Disopyramide Dofetilide Dronedarone Quinidine a Contraindicated during and 2 weeks after itraconazole treatment.
Multaq
Sporanox
Multaq is a medicine that helps lower the risk of needing to stay in the hospital for atrial fibrillation (AFib). It is for people who have a history of AFib and are currently in normal heart rhythm.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Multaq is used to lower the risk of hospitalization if you have atrial fibrillation (AFib). AFib is an irregular heartbeat. This medicine is for people who used to have AFib, but are now in a normal heart rhythm.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Multaq is an antiarrhythmic drug. It works by changing the electrical signals in the heart. This helps to keep your heart in a normal rhythm and prevent AFib from returning.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Diarrhea
- • Nausea
- • Abdominal pain
- • Vomiting
- • Feeling weak or tired
- • Nausea
- • Rash
- • Headache
- Atrial Fibrillation 1,420
- Dyspnoea 838
- Fatigue 615
- Diarrhoea 477
- Nausea 472
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Multaq can increase the risk of death, stroke, and heart failure in patients with severe heart failure or permanent AFib. You should not take this medicine if you have severe heart failure that recently required hospitalization or if you have permanent AFib and will not be converted to a normal heart rhythm.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Multaq can harm an unborn baby. If you are a woman who could become pregnant, use effective birth control while taking Multaq. Do not breastfeed while taking Multaq and for 5 days after your last dose.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This dronedarone vs itraconazole Comparison
dronedarone is classified in the Class III Antiarrhythmic drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dronedarone has 3,822 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole slows down how fast your body removes dronedarone, which can lead to serious heart rhythm problems from too much medicine.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dronedarone or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.