dronabinol vs fluconazole
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Side-by-side comparison of dronabinol and fluconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Monitor for potentially increased dronabinol-related adverse reactions when dronabinol capsules are co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice).
Marinol
Diflucan
Dronabinol capsules contain a synthetic form of THC, the active ingredient in marijuana. It is used to treat loss of appetite in AIDS patients and nausea/vomiting from chemotherapy.
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Dronabinol is used to treat loss of appetite and weight loss in adults with Acquired Immune Deficiency Syndrome (AIDS). It also helps with nausea and vomiting caused by cancer chemotherapy when other treatments don't work well. Dronabinol can help you eat more and feel less sick.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Dronabinol works by activating cannabinoid receptors in your brain. These receptors affect appetite, mood, and the sensation of nausea. By activating these receptors, dronabinol can increase appetite and reduce nausea and vomiting.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
- • Abdominal pain
- • Dizziness
- • Feeling very happy
- • Nausea
- • Feeling paranoid
- • Headache
- • Nausea
- • Abdominal pain
- Nausea 878
- Fatigue 696
- Diarrhoea 604
- Death 593
- Vomiting 580
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
Dronabinol can cause mental and mood changes. Tell your doctor if you have a history of mental illness. Do not drive or operate heavy machinery until you know how this medicine affects you. This medicine can also affect your heart, causing changes in blood pressure or heart rate. Dronabinol may also increase the risk of seizures.
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Dronabinol may harm your unborn baby. Avoid using this medicine if you are pregnant. If you are breastfeeding and have HIV, do not breastfeed due to the risk of passing HIV to your baby.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
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How to Read This dronabinol vs fluconazole Comparison
dronabinol is classified in the Cannabinoid Antiemetic drug class, while fluconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dronabinol has 3,351 submissions while fluconazole has 17,630. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole stops the liver from breaking down dronabinol, which can lead to higher levels of the drug in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dronabinol or fluconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.