dofetilide vs itraconazole
Side-by-side comparison of dofetilide and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Antiarrhythmics Disopyramide Dofetilide Dronedarone Quinidine a Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: Avoid taking these two medicines together and wait two weeks after stopping itraconazole before starting dofetilide.
Tikosyn
Sporanox
Dofetilide (Tikosyn) helps keep your heart in a normal rhythm if you have atrial fibrillation or atrial flutter. It can also help convert these abnormal rhythms back to normal.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
This medicine is used to maintain a normal heart rhythm if you have atrial fibrillation or atrial flutter for more than a week, and your heart has been returned to a normal rhythm. It can also convert atrial fibrillation and atrial flutter to a normal rhythm. This medicine is for people who have bothersome symptoms from their atrial fibrillation or flutter.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Dofetilide belongs to a class of drugs called Class III antiarrhythmics. It works by changing the electrical activity in your heart. This helps to stabilize your heart rhythm and prevent irregular heartbeats.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Headache
- • Chest pain
- • Dizziness
- • Nausea
- • Rash
- • Headache
- Irregular heartbeat 1,059
- Shortness of breath 603
- Feeling lightheaded 552
- Feeling tired 521
- Death 478
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
This drug can cause life-threatening heart rhythm problems. To lower this risk, you must start or restart this medicine in a hospital where your heart can be watched closely for at least 3 days. The hospital staff will check your kidney function and heart rhythm regularly.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This dofetilide vs itraconazole Comparison
dofetilide is classified in the Class III Antiarrhythmic drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dofetilide has 3,213 submissions while itraconazole has 3,068. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole interferes with the way your body breaks down dofetilide, potentially causing the heart medication to reach dangerous levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dofetilide and itraconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.