diltiazem vs fesoterodine
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Side-by-side comparison of diltiazem and fesoterodine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem, verapamil and grapefruit juice).
Cardizem, Tiazac
Toviaz
Diltiazem is a medicine that helps lower high blood pressure and prevent chest pain. It belongs to a class of drugs called calcium channel blockers.
Fesoterodine is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
Diltiazem is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. Diltiazem also helps manage chronic stable angina (chest pain) and angina caused by spasms in the heart's blood vessels.
This medicine treats overactive bladder (OAB) in adults. OAB can cause you to feel a sudden need to urinate. It can also cause you to urinate more often than normal, and leak urine.
Diltiazem works by relaxing blood vessels, which lowers blood pressure. It also reduces the heart's workload, which can prevent chest pain. This medicine blocks calcium from entering heart and blood vessel cells.
Fesoterodine belongs to a class of drugs called anticholinergics. It works by blocking certain nerve signals to the bladder. This helps to relax the bladder muscles and reduce the urge to urinate.
- • Swelling in your ankles or feet
- • Headache
- • Dizziness
- • Slow heart rate
- • Constipation
- • Dry mouth
- • Constipation
- Dyspnoea 3,202
- Fatigue 2,638
- Nausea 2,372
- Pain 2,365
- Dizziness 2,091
- Dry mouth 823
- Fall 529
- Tiredness 505
- Constipation 503
- Unable to empty bladder 502
Diltiazem can interact with other heart medications. Tell your doctor if you take beta-blockers or digoxin. Using diltiazem with these drugs can cause heart problems. Your doctor may need to adjust your dosages.
Fesoterodine can cause swelling of the face, lips, tongue, or throat. This can be life-threatening, so stop taking the medicine and get medical help right away if this happens. Fesoterodine is not recommended if you have a blockage in your bladder or have problems with food moving through your digestive system. Use with caution if you have narrow-angle glaucoma or myasthenia gravis.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if diltiazem will harm your unborn baby. Diltiazem passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
It is not known if fesoterodine can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if fesoterodine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
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How to Read This diltiazem vs fesoterodine Comparison
diltiazem is classified in the Calcium Channel Blocker drug class, while fesoterodine sits within the Anticholinergic (Overactive Bladder) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diltiazem has 12,668 submissions while fesoterodine has 2,862. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to diltiazem blocks the enzyme that breaks down fesoterodine, which can slightly increase the amount of medicine in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diltiazem or fesoterodine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.