fesoterodine vs solifenacin
Side-by-side comparison of fesoterodine and solifenacin Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Toviaz
Vesicare
Fesoterodine is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
Solifenacin (Vesicare) is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
This medicine treats overactive bladder (OAB) in adults. OAB can cause you to feel a sudden need to urinate. It can also cause you to urinate more often than normal, and leak urine.
This medicine treats overactive bladder in adults. It helps with symptoms like needing to urinate urgently, frequent urination, and leaking urine. It works to reduce these urges and help you control your bladder.
Fesoterodine belongs to a class of drugs called anticholinergics. It works by blocking certain nerve signals to the bladder. This helps to relax the bladder muscles and reduce the urge to urinate.
Solifenacin blocks certain receptors in the bladder called muscarinic receptors. By blocking these receptors, the bladder muscle relaxes. This helps to reduce the urge to urinate frequently and reduces leakage.
- • Dry mouth
- • Constipation
- • Dry mouth
- • Constipation
- • Urinary tract infection
- • Blurred vision
- Drug not working 1,662
- Dry mouth 823
- Fall 529
- Tiredness 505
- Using the drug for something it's not approved for 505
- Medicine not working 3,600
- Dry mouth 1,616
- Constipation 1,613
- Tiredness 1,275
- Using medicine for unapproved purpose 1,236
Fesoterodine can cause swelling of the face, lips, tongue, or throat. This can be life-threatening, so stop taking the medicine and get medical help right away if this happens. Fesoterodine is not recommended if you have a blockage in your bladder or have problems with food moving through your digestive system. Use with caution if you have narrow-angle glaucoma or myasthenia gravis.
This medicine may cause swelling of the face, lips, tongue, or throat. If this happens, stop taking solifenacin and get medical help right away. This medicine is not recommended if you have a bladder problem that makes it hard to empty your bladder. It is also not recommended if you have slow movement in your stomach or intestines. This medicine may cause sleepiness, so be careful driving or operating heavy machinery until you know how it affects you.
It is not known if fesoterodine can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if fesoterodine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if solifenacin can harm your unborn baby. It is also not known if solifenacin passes into breast milk.
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How to Read This fesoterodine vs solifenacin Comparison
fesoterodine is classified in the Anticholinergic (Overactive Bladder) drug class, while solifenacin sits within the Anticholinergic (Overactive Bladder) class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fesoterodine has 4,024 submissions while solifenacin has 9,340. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fesoterodine and solifenacin — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.