digoxin vs risperidone
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Side-by-side comparison of digoxin and risperidone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Digoxin Risperidone tablets (0.25 mg twice daily) did not show a clinically relevant effect on the pharmacokinetics of digoxin. Dose adjustment for digoxin is not recommended.
Lanoxin
Risperdal
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Risperidone is a medicine used to treat certain mental disorders. It can help reduce symptoms like hallucinations, delusions, and aggression.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Risperidone is used to treat schizophrenia in adults and teens. It also treats manic or mixed episodes of bipolar I disorder, either alone or with lithium or valproate. Additionally, it can help with irritability, including aggression and self-injury, in children and teens with autism.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Risperidone works by changing the levels of certain natural substances in the brain. These substances are called neurotransmitters. By balancing these chemicals, risperidone can reduce symptoms of mental disorders.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Parkinsonism (slowed movement, stiffness)
- • Restlessness
- • Muscle stiffness or spasms
- • Tremors
- • Sleepiness
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Gynaecomastia 24,608
- Abnormal Weight Gain 9,446
- Weight Increased 9,088
- Emotional Disorder 5,947
- Injury 4,623
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Risperidone may increase the risk of death in elderly patients who have dementia-related psychosis. Risperidone is not approved for treating dementia-related psychosis.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take risperidone in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to monitor outcomes in women exposed to risperidone during pregnancy. You can contact the registry at 1-866-961-2388.
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How to Read This digoxin vs risperidone Comparison
digoxin is classified in the Cardiac Glycoside drug class, while risperidone sits within the Atypical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while risperidone has 53,712. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to risperidone does not have a meaningful effect on how your body handles digoxin.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or risperidone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.