dexlansoprazole vs rabeprazole
Side-by-side comparison of dexlansoprazole and rabeprazole Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Dexilant
Aciphex
Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Rabeprazole (Aciphex) is a medicine that reduces the amount of acid your stomach makes. It belongs to a class of drugs called proton pump inhibitors (PPIs).
This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach). It can also help with heartburn caused by acid reflux. Dexlansoprazole can also treat heartburn from GERD, a condition where stomach acid flows back into your esophagus.
This medicine can treat several conditions caused by too much stomach acid. It can heal damage to your esophagus from acid reflux (GERD). It also treats heartburn, stomach ulcers, and conditions like Zollinger-Ellison syndrome where the body makes too much acid. Rabeprazole can also be used with antibiotics to get rid of a bacteria called H. pylori that can cause ulcers.
Dexlansoprazole works by reducing the amount of acid your stomach makes. It does this by blocking a specific system in your stomach cells. This helps to heal damage caused by stomach acid.
Rabeprazole works by blocking the enzyme in your stomach that produces acid. This helps to lower the amount of acid in your stomach. Lowering stomach acid helps to heal damage and relieve symptoms.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Upper respiratory tract infection
- • Vomiting
- • Pain
- • Sore throat
- • Gas
- • Infection
- • Constipation
- Long-term kidney disease 16,100
- Sudden kidney damage 7,791
- Kidney failure 6,721
- Kidney failure requiring dialysis 4,842
- Kidney damage 4,339
- The medicine is not working 1,859
- Using the medicine for a condition it's not approved for 1,771
- Feeling sick to your stomach 1,543
- Loose, watery stools 1,318
- Aches or soreness 1,314
Dexlansoprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. It can also cause kidney problems, severe diarrhea from a Clostridium difficile infection, and bone fractures with long-term use. Some people may have severe skin reactions or lupus. Long-term use may also lead to low vitamin B12 or magnesium levels.
Taking PPIs like rabeprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. This medicine may also increase your risk of bone fractures, especially if you take it for a long time or at high doses. Long-term use may also cause low vitamin B12 or magnesium levels. Contact your doctor right away if you experience signs of hypersensitivity.
Based on animal studies, this medicine may harm a developing baby's bones. Talk to your doctor if you are pregnant or plan to become pregnant.
It is not known if rabeprazole is safe to use during pregnancy. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
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How to Read This dexlansoprazole vs rabeprazole Comparison
dexlansoprazole is classified in the Proton Pump Inhibitor (PPI) drug class, while rabeprazole sits within the Proton Pump Inhibitor (PPI) class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dexlansoprazole has 39,793 submissions while rabeprazole has 7,805. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dexlansoprazole and rabeprazole — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.