clobazam vs fluconazole
Side-by-side comparison of clobazam and fluconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Recommendation: Your healthcare provider may need to adjust your clobazam dosage. Let your doctor know if you feel more tired or dizzy than usual.
Onfi, Sympazan
Diflucan
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome. It is a type of drug called a benzodiazepine.
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Clobazam oral suspension is used to treat seizures in people 2 years and older who have Lennox-Gastaut syndrome (LGS). LGS is a severe form of epilepsy that begins in childhood. This medicine helps to control seizures when used with other seizure medicines.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Clobazam belongs to a class of drugs called benzodiazepines. It works by affecting certain chemicals in the brain that may be unbalanced in people with seizures. This helps to reduce the frequency of seizures.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
- • Constipation
- • Sleepiness or drowsiness
- • Fever
- • Sluggishness
- • Drooling
- • Headache
- • Nausea
- • Abdominal pain
- Seizure 4,619
- Sleepiness 1,798
- Medicine interaction 1,123
- Tiredness 1,090
- Epilepsy 805
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
Clobazam can cause serious side effects: * **Risk of Using with Opioids:** Taking clobazam with opioid medicines can cause severe sleepiness, slowed breathing, coma, and death. Only take them together if no other treatment works, and use the lowest dose for the shortest time. * **Risk of Abuse, Misuse, and Addiction:** Clobazam can be abused, misused, and lead to addiction, overdose or death. Your doctor will assess your risk before and during treatment. * **Risk of Dependence and Withdrawal:** Taking clobazam can lead to physical dependence. Stopping it suddenly can cause life-threatening withdrawal symptoms. To stop, your doctor will slowly lower your dose.
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Clobazam may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take anti-epilepsy drugs like clobazam. You can enroll by calling 1-888-233-2334.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Also Compare, Nearby Drugs
Compare fluconazole with
How to Read This clobazam vs fluconazole Comparison
clobazam is classified in the Benzodiazepine (Anticonvulsant) drug class, while fluconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clobazam has 9,435 submissions while fluconazole has 17,625. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole blocks the specific enzyme that clears clobazam from your system. this makes the clobazam stay in your body longer and can increase its effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between clobazam and fluconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.