chlorzoxazone vs lemborexant
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of chlorzoxazone and lemborexant. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Parafon Forte
Dayvigo
Chlorzoxazone is a muscle relaxant. It helps to relieve discomfort from painful muscle problems.
Dayvigo is a medicine that can help you fall asleep and stay asleep. It is for adults who have trouble with insomnia.
This medicine treats discomfort from muscle problems. It is used with rest and physical therapy. It helps with acute, painful muscle and bone conditions.
Dayvigo is used to treat insomnia in adults. Insomnia means you have trouble falling asleep, staying asleep, or both. This medicine can help you sleep better.
The way this drug works is not fully known. It may work by making you feel sleepy. This medicine does not directly relax your muscles.
Dayvigo works by blocking orexin, a chemical in your brain that keeps you awake. By blocking orexin, Dayvigo helps you feel sleepy. This allows you to fall asleep and stay asleep.
- • Drowsiness
- • Dizziness
- • Lightheadedness
- • Feeling unwell
- • Over-stimulation
- • Feeling sleepy
- Dizziness 94
- Nausea 94
- Fatigue 92
- Pain 90
- Headache 72
- Suicide Attempt 133
- Somnolence 128
- Condition Aggravated 117
- Suicidal Ideation 115
- Fall 94
If you are intolerant to chlorzoxazone, you should not take this medicine.
Dayvigo can make you feel very sleepy, even the next day. Be careful driving or doing other things that need you to be alert. Some people have sleep paralysis, hallucinations, or do things like sleepwalking while taking Dayvigo. Dayvigo may also worsen depression or suicidal thoughts. Do not drink alcohol while taking Dayvigo.
Talk to your doctor if you are pregnant or breastfeeding. It is not known if this medicine will harm your unborn baby. It is also not known if this medicine passes into breast milk.
It is not known if Dayvigo can harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take psychiatric medicines, including Dayvigo.
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How to Read This chlorzoxazone vs lemborexant Comparison
chlorzoxazone is classified in the Muscle Relaxant drug class, while lemborexant sits within the Orexin Receptor Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, chlorzoxazone has 442 submissions while lemborexant has 587. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to chlorzoxazone slows down the process your body uses to get rid of lemborexant. this may lead to higher levels of the sleep medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for chlorzoxazone or lemborexant.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.