Two medicines, side by side
Chlordiazepoxide vs clonazepam
Chlordiazepoxide and clonazepam are both labeled for anxiety. Drugs@FDA records approvals of chlordiazepoxide since 1960 and of clonazepam since 1975. Pharmacies paid $0.158 per chlordiazepoxide 25 mg capsule and $0.0244 per clonazepam 1 mg tablet (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like.
Check it at the source: the chlordiazepoxide FDA label on DailyMed (effective December 10, 2025); the clonazepam FDA label on DailyMed (effective December 1, 2025).
Highlights of the chlordiazepoxide record
Chlordiazepoxide (Librium) · label of December 10, 2025
RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; AND DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required.
Used for
From the label: indicationsChlordiazepoxide Hydrochloride Capsules are indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. […]
On the market
- Earliest approval on file
- February 24, 1960
- Generic labelers
- 15 labelers
- Pharmacy cost
- $0.158 per capsule
Supply and safety
- Shortage
- No current entry
- Recalls
- 0
Highlights of the clonazepam record
Clonazepam (Klonopin) · label of December 1, 2025
RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required.
Used for
From the label: indicationsSeizure Disorders Klonopin is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Klonopin may be useful. Some loss of effect may occur during the course of clonazepam treatment (see PRECAUTIONS: Loss of Effect ). […]
On the market
- Earliest approval on file
- June 4, 1975
- Generic labelers
- 31 labelers
- Pharmacy cost
- $0.0244 per tablet
Supply and safety
- Shortage
- In shortage
- Recalls
- 7
Source: FDA drug labels via openFDA (Chlordiazepoxide label of December 10, 2025, Clonazepam label of December 1, 2025); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do chlordiazepoxide and clonazepam differ on the record?
Both are in FDA's class benzodiazepines.
Half-life, in each label's words: Chlordiazepoxide, “It takes several hours for peak blood levels to be reached and the half-life of the drug is between 24 and 48 hours.”; Clonazepam, “The elimination half-life of clonazepam is typically 30 to 40 hours.”
Both labels carry a boxed warning; the records quote them.
Generics: chlordiazepoxide since 1975; clonazepam since 1996 (Drugs@FDA).
| Chlordiazepoxide | Clonazepam | |
|---|---|---|
| Labeled for | Anxiety, Alcohol use disorder | Seizures and epilepsy, Anxiety |
| Pharmacologic class | Benzodiazepine | Benzodiazepine |
| How it works (label) | n/a | n/a |
| Half-life (label) | It takes several hours for peak blood levels to be reached and the half-life of the drug is between 24 and 48 hours. | The elimination half-life of clonazepam is typically 30 to 40 hours. |
| Earliest approval on file (Drugs@FDA) | February 24, 1960 | June 4, 1975 |
| First generic approved | March 7, 1975 | September 10, 1996 |
| Generic labelers (NDC) | 15 labelers | 31 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.158 per capsule (Chlordiazepoxide 25 mg capsule) | $0.0244 per tablet (Clonazepam 1 mg tablet) |
| 12-month price change | -2% | -14% |
| Boxed warning | Yes | Yes |
| Shortage now | No current entry | In shortage |
| Recalls recorded | 0 | 7 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 107 | 159,283 |
| DEA schedule | CIV | CIV |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to chlordiazepoxide
- every medicine labeled for the same conditions