brexpiprazole vs iloperidone
Side-by-side comparison of brexpiprazole and iloperidone Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Rexulti
Fanapt
Rexulti is a medication used to treat certain mental health conditions. It can help with depression, schizophrenia, and agitation related to Alzheimer's disease.
Fanapt is a medicine used to treat schizophrenia and bipolar disorder. It helps to balance chemicals in the brain to improve mood and behavior.
Rexulti can be used with antidepressants to treat major depressive disorder in adults. It can also treat schizophrenia in adults and children 13 years and older. Additionally, Rexulti can help manage agitation in people with dementia due to Alzheimer's disease. Rexulti should not be used as needed for agitation related to dementia.
Fanapt is used to treat schizophrenia in adults. Schizophrenia can cause confused thinking, hallucinations, and changes in behavior. Fanapt is also used for the short-term treatment of manic or mixed episodes linked to bipolar I disorder in adults.
Rexulti affects the balance of certain natural chemicals in the brain. These chemicals, called neurotransmitters, include dopamine and serotonin. By affecting these chemicals, Rexulti can help improve mood, thinking, and behavior.
Fanapt is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to reduce symptoms of schizophrenia and bipolar disorder.
- • Weight gain
- • Feeling sleepy
- • Restlessness or feeling like you need to move
- • Dizziness
- • Dry mouth
- • Feeling tired
- • Stuffy nose
- • Low blood pressure when standing up
- Weight gain 1,673
- Using the medicine for a condition it is not approved for 1,277
- Using the medicine for a condition it is not approved for 1,092
- The medicine is not working 929
- Restlessness or feeling like you need to move 854
- The medicine is not working 107
- Feeling lightheaded or unsteady 99
- Trouble sleeping 83
- Gaining weight 76
- Feeling worried or nervous 68
Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death. Rexulti is not approved to treat dementia-related psychosis unless it is related to agitation from Alzheimer's disease. Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults and children. Tell your doctor right away if you have thoughts of harming yourself.
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia. Fanapt is not approved to treat this condition.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take Rexulti in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to monitor outcomes in women exposed to Rexulti during pregnancy. You can contact the registry at 1-866-961-2388.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take antipsychotics like Fanapt in the last 3 months of pregnancy may have withdrawal symptoms after birth. Talk to your doctor about whether to breastfeed while taking Fanapt.
Also Compare — Nearby Drugs
Compare brexpiprazole with
Compare iloperidone with
How to Read This brexpiprazole vs iloperidone Comparison
brexpiprazole is classified in the Atypical Antipsychotic drug class, while iloperidone sits within the Atypical Antipsychotic class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, brexpiprazole has 5,825 submissions while iloperidone has 433. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between brexpiprazole and iloperidone — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.