asenapine vs iloperidone
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of asenapine and iloperidone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Saphris
Fanapt
Asenapine (Saphris) is an antipsychotic medicine. It is used to treat bipolar I disorder in adults and children ages 10-17.
Fanapt is a medicine used to treat schizophrenia and bipolar disorder. It helps to balance chemicals in the brain to improve mood and behavior.
Asenapine is used to treat bipolar I disorder. In children ages 10 to 17, it can treat manic or mixed episodes on its own. In adults, it can be used with lithium or valproate to treat these episodes.
Fanapt is used to treat schizophrenia in adults. Schizophrenia can cause confused thinking, hallucinations, and changes in behavior. Fanapt is also used for the short-term treatment of manic or mixed episodes linked to bipolar I disorder in adults.
Asenapine affects certain chemicals in the brain. These chemicals are called neurotransmitters. By changing the balance of these chemicals, asenapine can help reduce symptoms of bipolar disorder.
Fanapt is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to reduce symptoms of schizophrenia and bipolar disorder.
- • Sleepiness
- • Numbness in the mouth
- • Dizziness
- • Changes in taste
- • Nausea
- • Dizziness
- • Dry mouth
- • Feeling tired
- • Stuffy nose
- • Low blood pressure when standing up
- Drug Interaction 78
- Toxicity To Various Agents 64
- Completed Suicide 61
- Myocarditis 53
- Sedation 39
- Dizziness 99
- Insomnia 83
- Weight Increased 76
- Anxiety 68
- Fatigue 66
Asenapine may increase the risk of death in elderly patients who have psychosis related to dementia. Asenapine is not approved to treat this condition.
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia. Fanapt is not approved to treat this condition.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who use antipsychotics in the last 3 months of pregnancy may have withdrawal symptoms after birth. There is a pregnancy registry, call 1-866-961-2388.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take antipsychotics like Fanapt in the last 3 months of pregnancy may have withdrawal symptoms after birth. Talk to your doctor about whether to breastfeed while taking Fanapt.
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How to Read This asenapine vs iloperidone Comparison
asenapine is classified in the Atypical Antipsychotic drug class, while iloperidone sits within the Atypical Antipsychotic class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, asenapine has 295 submissions while iloperidone has 392. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for asenapine or iloperidone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.