aripiprazole vs itraconazole
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of aripiprazole and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Important Interactions with Aripiprazole Table 25: Clinically Important Drug Interactions with...
Abilify
Sporanox
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems. It can help to improve your mood, thinking, and behavior.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Aripiprazole is used to treat schizophrenia in adults and teens. It also treats irritability in children with autism. Additionally, it can treat Tourette's disorder.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Aripiprazole works by affecting the levels of certain chemicals in the brain. These chemicals, like dopamine and serotonin, can affect mood and behavior. By balancing these chemicals, aripiprazole helps to reduce symptoms of mental health conditions.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Nausea
- • Vomiting
- • Constipation
- • Headache
- • Dizziness
- • Nausea
- • Rash
- • Headache
- Weight Increased 7,698
- Anxiety 4,993
- Fatigue 4,188
- Suicidal Ideation 3,991
- Depression 3,950
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Aripiprazole may increase the risk of death in elderly patients who have psychosis related to dementia. It is not approved for this use. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Watch closely for worsening mood or suicidal thoughts.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
If you are pregnant or plan to become pregnant, talk to your doctor. Aripiprazole may cause withdrawal symptoms or other problems in newborns if taken during the third trimester. There is a pregnancy registry for women who take aripiprazole during pregnancy.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This aripiprazole vs itraconazole Comparison
aripiprazole is classified in the Atypical Antipsychotic drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aripiprazole has 24,820 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole blocks the enzymes that normally break down aripiprazole, which can lead to higher levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for aripiprazole or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.