aprepitant vs itraconazole
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of aprepitant and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Aprepitant Loperamide a Monitor for adverse reactions.
Emend
Sporanox
Aprepitant (Emend) is a medicine that helps prevent nausea and vomiting. It belongs to a class of drugs called NK1 receptor antagonists.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Aprepitant is used to prevent nausea and vomiting caused by chemotherapy. It can be used for both strong and moderate chemotherapy treatments. It is also used to prevent nausea and vomiting after surgery in adults.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Aprepitant blocks a substance in your body called substance P. Substance P can trigger nausea and vomiting. By blocking it, aprepitant helps reduce these side effects.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Tiredness
- • Diarrhea
- • Weakness
- • Upset stomach
- • Stomach pain
- • Nausea
- • Rash
- • Headache
- Nausea 2,145
- Fatigue 1,769
- Pyrexia 1,589
- Diarrhoea 1,542
- Dyspnoea 1,508
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Aprepitant can interact with other medicines. It can affect how well warfarin (a blood thinner) and hormonal birth control work. If you take warfarin, your doctor will check your blood. If you use hormonal birth control, use a backup method while taking aprepitant and for 28 days after your last dose.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
There is not enough information about the safety of aprepitant during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if aprepitant passes into breast milk, so discuss breastfeeding with your doctor.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This aprepitant vs itraconazole Comparison
aprepitant is classified in the NK1 Receptor Antagonist (Antiemetic) drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aprepitant has 8,553 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole slows down the body's ability to process aprepitant, which can cause the drug to stay in your system longer.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for aprepitant or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.