amphotericin B vs fludrocortisone
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Side-by-side comparison of amphotericin B and fludrocortisone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.
Ambisome, Fungizone
Florinef
Amphotericin B liposome is an antifungal medicine. It fights serious fungal infections in your body.
Fludrocortisone is a medicine that helps your body balance salt and fluids. It is used when your adrenal glands don't make enough of certain hormones.
This medicine treats fungal infections like aspergillosis, candidiasis, and cryptococcosis. It can also treat cryptococcal meningitis in people with HIV. It may also be used for visceral leishmaniasis, but this infection can return, especially in those with weak immune systems.
This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome. These conditions happen when your adrenal glands don't make enough of certain hormones. Fludrocortisone helps your body hold onto salt and water, which is important for these conditions.
Amphotericin B liposome belongs to a class of drugs called polyene antifungals. It works by binding to the membrane of the fungal cells. This binding disrupts the fungal cell membrane, causing the cell to die.
Fludrocortisone is a mineralocorticoid. It works by helping your body to retain sodium and water. This helps to increase blood volume and blood pressure.
- • Abdominal pain
- • Weakness
- • Back pain
- • Chills
- • Pain
- • High blood pressure
- • Swelling in your hands, feet, or ankles
- • Enlarged heart
- • Heart failure
- • Loss of potassium
- Pyrexia 972
- Condition Aggravated 841
- Febrile Neutropenia 650
- Acute Kidney Injury 625
- Sepsis 613
- Feeling tired 146
- Falling down 144
- Feeling lightheaded 135
- Feeling sick to your stomach 129
- Death 126
This medicine is not interchangeable with other amphotericin B products. Different versions of amphotericin B act differently in the body. Make sure you always get the correct medicine.
This medicine may cause you to retain too much sodium and water, leading to high blood pressure, swelling, and heart problems. Tell your doctor right away if you have any of these symptoms. This medicine can also interact with other medicines, so be sure to tell your doctor about all the medicines you are taking.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of using this medicine during pregnancy or while breastfeeding.
Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is not known if this medicine will harm your unborn baby. It is also not known if this medicine passes into breast milk.
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How to Read This amphotericin B vs fludrocortisone Comparison
amphotericin B is classified in the Polyene Antifungal drug class, while fludrocortisone sits within the Mineralocorticoid class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amphotericin B has 3,701 submissions while fludrocortisone has 680. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medications can cause your body to lose potassium. taking them together increases the risk of your potassium levels becoming dangerously low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for amphotericin B or fludrocortisone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.