aliskiren vs benazepril
Side-by-side comparison of aliskiren and benazepril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7.4 Dual Blockade of the Renin-Angiotensin System (RAS) Dual Blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with benazepril hydrochloride in patients with diabetes. Avoid use of aliskiren with benazepril hydrochloride in patients with renal impairment (GFR < 60 ml/min).
Recommendation: This combination should not be used in patients with diabetes or kidney disease. Talk to your doctor about using only one of these medications to protect your kidneys.
Tekturna
Lotensin
Tekturna is a medicine used to treat high blood pressure. It helps lower blood pressure, which can reduce the risk of strokes and heart attacks.
Benazepril (Lotensin) is a medicine that lowers your blood pressure. Lowering blood pressure helps to prevent strokes and heart attacks.
Tekturna is used to treat high blood pressure in adults and children who weigh at least 110 pounds and are 6 years or older. Lowering your blood pressure helps prevent strokes and heart attacks. It is important to manage high blood pressure with a healthy lifestyle too.
Benazepril is used to treat high blood pressure (hypertension). Lowering your blood pressure reduces your risk of heart attack and stroke. It can be used alone or with other blood pressure medicines.
Tekturna works by blocking a substance in your body called renin. Renin helps to control your blood pressure. By blocking renin, Tekturna helps to lower your blood pressure.
Benazepril is an ACE inhibitor. It works by relaxing your blood vessels. This makes it easier for your heart to pump blood.
- • Diarrhea
- • Headache
- • Dizziness
- • Feeling sleepy
- • Dizziness when standing up
- Weakness 367
- Fall 356
- Feeling sick to your stomach 336
- Shortness of breath 314
- Headache 301
- Feeling sick to your stomach 439
- Feeling tired 408
- Feeling lightheaded 382
- Difficulty breathing 380
- Discomfort 361
Tekturna can harm your unborn baby, even causing death. If you become pregnant, stop taking Tekturna right away and tell your doctor.
If you become pregnant, stop taking benazepril right away and tell your doctor. This medicine can harm or kill your unborn baby.
Tekturna can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor about other blood pressure medicines. Breastfeeding is not recommended while taking Tekturna.
Benazepril can cause serious harm to your unborn baby, including death. Stop taking it as soon as you know you are pregnant. Talk to your doctor about other blood pressure medicines if you are planning to become pregnant.
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How to Read This aliskiren vs benazepril Comparison
aliskiren is classified in the Direct Renin Inhibitor drug class, while benazepril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aliskiren has 1,674 submissions while benazepril has 1,970. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to these medicines both target the same pathway for blood pressure control, which increases the risk of kidney failure and high potassium. using them together can cause your blood pressure to fall to unsafe levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aliskiren and benazepril - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.