Two medicines, side by side
Acetaminophen/oxycodone vs amoxicillin
Acetaminophen/oxycodone is labeled for pain; amoxicillin for bacterial infections and acid reflux and ulcers. Their labels share no use, so they are not alternatives to each other. Drugs@FDA records approvals of acetaminophen/oxycodone since 2014 and of amoxicillin since 1974. Pharmacies paid $0.183 per oxycodone-acetaminophen 7.5-325 mg tablet and $0.0788 per amoxicillin 500 mg capsule (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. In FDA's classes, acetaminophen/oxycodone is an opioid agonist and amoxicillin a penicillin-class antibacterial.
Check it at the source: the acetaminophen/oxycodone FDA label on DailyMed (effective December 23, 2025); the amoxicillin FDA label on DailyMed (effective February 22, 2024).
Highlights of the acetaminophen and oxycodone record
Acetaminophen and oxycodone (Percocet) · label of December 23, 2025
ADDICTION, ABUSE, AND MISUSE: RISK EVALUATION AND MITIGATION STRATEGY (REMS); LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME;
Used for
From the label: indicationsOxycodone and acetaminophen tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. […]
On the market
- Earliest approval on file
- March 11, 2014
- Generic labelers
- 29 labelers
- Pharmacy cost
- $0.183 per tablet
Supply and safety
- Shortage
- A presentation being discontinued
- Recalls
- 8
Highlights of the amoxicillin record
Amoxicillin (Amoxil) · label of February 22, 2024
Used for
From the label: indicationsAdults and Pediatric Patients • Upper Respiratory Tract Infections of the Ear, Nose, and Throat Amoxicillin is indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species. (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp. , or Haemophilus influenzae. […]
On the market
- Earliest approval on file
- January 18, 1974
- Generic labelers
- 38 labelers
- Pharmacy cost
- $0.0788 per capsule
Supply and safety
- Shortage
- No current entry
- Recalls
- 12
Source: FDA drug labels via openFDA (Acetaminophen/oxycodone label of December 23, 2025, Amoxicillin label of February 22, 2024); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do acetaminophen/oxycodone and amoxicillin differ on the record?
In FDA's classes, acetaminophen/oxycodone is an opioid agonist and amoxicillin a penicillin-class antibacterial.
Half-life, in each label's words: Acetaminophen/oxycodone, “The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage.”; Amoxicillin, “Metabolism and Excretion The half-life of amoxicillin is 61.3 minutes.”
Only the acetaminophen/oxycodone label carries a boxed warning.
Generics: acetaminophen/oxycodone since 1976; amoxicillin since 1974 (Drugs@FDA).
DEA schedule: acetaminophen/oxycodone CII; amoxicillin none.
| Acetaminophen/oxycodone | Amoxicillin | |
|---|---|---|
| Labeled for | Pain | Bacterial infections, Acid reflux and ulcers |
| Pharmacologic class | Opioid Agonist | Penicillin-class Antibacterial |
| How it works (label) | n/a | Amoxicillin is an antibacterial drug [see Microbiology ( 12.4 )]. |
| Half-life (label) | The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. | Metabolism and Excretion The half-life of amoxicillin is 61.3 minutes. |
| Earliest approval on file (Drugs@FDA) | March 11, 2014 | January 18, 1974 |
| First generic approved | August 31, 1976 | December 9, 1974 |
| Generic labelers (NDC) | 29 labelers | 38 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.183 per tablet (Oxycodone-acetaminophen 7.5-325 mg tablet) | $0.0788 per capsule (Amoxicillin 500 mg capsule) |
| 12-month price change | +2% | -12% |
| Boxed warning | Yes | No |
| Shortage now | A presentation being discontinued | No current entry |
| Recalls recorded | 8 | 12 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 23,353 | 75,926 |
| DEA schedule | CII | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What do the labels say about using others of their kind?
Acetaminophen/oxycodone label, drug interactionsBenzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids and other opioids, including alcohol, can increase the risk of hypotension, respiratory …
Source: FDA drug labels via openFDA
What next?
- Alternatives to acetaminophen/oxycodone
- every medicine labeled for the same conditions