abiraterone vs thioridazine
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Side-by-side comparison of abiraterone and thioridazine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Avoid co-administration of abiraterone acetate with substrates of CYP2D6 with a narrow therapeutic index (e.g., thioridazine).
Zytiga
Mellaril
Abiraterone (Zytiga) is a medicine used with prednisone to treat prostate cancer that has spread. It works by lowering the amount of androgen your body makes.
Thioridazine is a medicine used to treat schizophrenia. It is only used when other antipsychotic medicines have not worked well enough.
Abiraterone is used to treat prostate cancer that has spread to other parts of the body. It is for cancers that are castration-resistant, meaning they no longer respond to hormone therapy alone. It is also used for high-risk castration-sensitive prostate cancer. You will take this medicine with prednisone.
Thioridazine is used to manage schizophrenia in adults and children. You should only use this medicine if other antipsychotic medicines have not worked for you. This is because thioridazine can cause serious heart problems.
Abiraterone blocks an enzyme called CYP17, which your body needs to make androgens. Androgens can help prostate cancer grow. By blocking this enzyme, abiraterone lowers androgen levels and slows cancer growth.
Thioridazine affects the balance of certain chemicals in the brain. These chemicals, like dopamine, can affect mood and behavior. By changing the balance, thioridazine helps to reduce symptoms of schizophrenia.
- • Feeling tired
- • Joint pain
- • High blood pressure
- • Feeling sick to your stomach
- • Swelling
- • Drowsiness
- • Dry mouth
- • Blurred vision
- • Constipation
- • Nausea
- Death 1,390
- Fatigue 1,023
- Hot Flush 678
- Asthenia 562
- Disease Progression 561
- Weight Increased 8
- Dyspnoea 7
- Dystonia 6
- Hyperglycaemia 6
- Hypoxia 6
Abiraterone can cause problems with mineralocorticoid excess, like high blood pressure, low potassium, and fluid retention. If you have heart problems, your doctor will monitor you closely. This medicine can also cause liver problems, which can be severe. Your doctor will check your liver function regularly. Do not take abiraterone with radium Ra 223 dichloride. Abiraterone can harm an unborn baby, so men should use effective birth control if their partner can get pregnant.
Thioridazine can cause a life-threatening heart rhythm problem called Torsades de pointes, which can lead to sudden death. Because of this risk, only use thioridazine if other antipsychotic medicines have not worked. Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death.
Abiraterone can cause harm to an unborn baby. Men who are taking abiraterone should use effective birth control during treatment and for 3 weeks after the last dose if their partner is able to get pregnant. It is not known if abiraterone passes into breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if thioridazine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking thioridazine during pregnancy and breastfeeding.
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How to Read This abiraterone vs thioridazine Comparison
abiraterone is classified in the CYP17 Inhibitor drug class, while thioridazine sits within the Typical Antipsychotic (Phenothiazine) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, abiraterone has 4,214 submissions while thioridazine has 33. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to abiraterone interferes with the enzyme that breaks down thioridazine. because thioridazine has a very narrow safety range, even a small increase in its levels could lead to dangerous side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for abiraterone or thioridazine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.