FDA pharmacologic class
Tricyclic antidepressants
9 medicines are in FDA's class of tricyclic antidepressants (tricyclic antidepressants): amitriptyline, doxepin (Silenor), nortriptyline (Pamelor), clomipramine (Anafranil), desipramine (Norpramin), imipramine, trimipramine, amoxapine and 1 more; 2 combination products also contain one. All 11 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is amitriptyline hcl 10 mg tablet at $0.03 per tablet (NADAC).
Which medicines are tricyclic antidepressants?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Amitriptyline | none listed | 34 labelers | $0.03 per tablet 10 mg tablet | Yes | No current entry | 2 |
| Doxepin | Silenor, Prudoxin, Zonalon | 49 labelers | $0.0779 per capsule 10 mg capsule | Yes | No current entry | 2 |
| Nortriptyline | Pamelor | 25 labelers | $0.113 per capsule 10 mg capsule | Yes | No current entry | 2 |
| Clomipramine | Anafranil | 16 labelers | $0.189 per capsule 25 mg capsule | Yes | No current entry | 7 |
| Desipramine | Norpramin | 9 labelers | $0.276 per tablet 75 mg tablet | Yes | No current entry | 6 |
| Imipramine | none listed | 14 labelers | $0.0698 per tablet 10 mg tablet | Yes | No current entry | 4 |
| Trimipramine | none listed | 3 labelers | n/a | Yes | No current entry | 0 |
| Amoxapine | none listed | 2 labelers | n/a | Yes | No current entry | 0 |
| Amitriptyline and perphenazine | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
| Protriptyline | none listed | 2 labelers | $2.71 per tablet 10 mg tablet | Yes | No current entry | 0 |
| Amitriptyline and chlordiazepoxide | none listed | 1 labeler | $1.20 per unit 5-12.5 | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price