FDA pharmacologic class
Serotonin Reuptake Inhibitor
8 medicines are in FDA's class of serotonin reuptake inhibitors: fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), trazodone (Raldesy), escitalopram (Lexapro), citalopram (Celexa), fluvoxamine and nefazodone; 1 combination product also contains one. All 9 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is citalopram hbr 10 mg tablet at $0.026 per tablet (NADAC).
Which medicines are serotonin reuptake inhibitor?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Fluoxetine | Prozac | 58 labelers | $0.0519 per capsule 40 mg capsule | Yes | No current entry | 9 |
| Sertraline | Zoloft | 47 labelers | $0.0507 per tablet 100 mg tablet | Yes | No current entry | 3 |
| Paroxetine | Paxil, Brisdelle | 45 labelers | $0.0611 per tablet 20 mg tablet | Yes | No current entry | 15 |
| Trazodone | Raldesy | 38 labelers | $0.0307 per tablet 50 mg tablet | Yes | No current entry | 5 |
| Escitalopram | Lexapro | 43 labelers | $0.0632 per tablet 20 mg tablet | Yes | No current entry | 1 |
| Citalopram | Celexa | 35 labelers | $0.026 per tablet 10 mg tablet | Yes | No current entry | 5 |
| Fluvoxamine | none listed | 16 labelers | $4.08 per capsule 100 mg capsule | Yes | No current entry | 0 |
| Fluoxetine and olanzapine | none listed | 3 labelers | $3.44 per unit 3-25 mg | Yes | No current entry | 0 |
| Nefazodone | none listed | 2 labelers | $1.17 per tablet 100 mg tablet | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price