FDA pharmacologic class
DPP-4 inhibitors
4 medicines are in FDA's class of dipeptidyl peptidase 4 inhibitors (DPP-4 inhibitors): sitagliptin (Januvia), alogliptin (Nesina), saxagliptin and linagliptin (Tradjenta); 8 combination products also contain one. 5 of the 12 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is saxagliptin hcl 5 mg tablet at $1.04 per tablet (NADAC).
Which medicines are dpp-4 inhibitors?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Metformin and sitagliptin | Zituvimet, Janumet | 4 labelers | $1.76 per tablet 50 mg-1,000 mg tablet | Yes | No current entry | 1 |
| Sitagliptin | Januvia, Zituvio, Brynovin | 4 labelers | $3.77 per tablet 100 mg tablet | No | No current entry | 1 |
| Alogliptin | Nesina | none listed | $4.96 per tablet 12.5 mg tablet | No | No current entry | 0 |
| Alogliptin and pioglitazone | Oseni | none listed | $4.73 per tablet 25-15 mg tablet | Yes | No current entry | 0 |
| Linagliptin and metformin | Jentadueto | 1 labeler | $8.44 per tablet 2.5 mg-1,000 mg tablet | Yes | No current entry | 1 |
| Metformin and saxagliptin | none listed | 2 labelers | $9.65 per tablet 5-1,000 mg tablet | Yes | No current entry | 0 |
| Saxagliptin | none listed | 3 labelers | $1.04 per tablet 5 mg tablet | No | No current entry | 2 |
| Alogliptin and metformin | Kazano | none listed | $2.46 per unit 12.5-1000 | Yes | No current entry | 0 |
| Empagliflozin and linagliptin and metformin | Trijardy | none listed | $11.28 per tablet 10-5-1,000 mg tablet | Yes | No current entry | 0 |
| Linagliptin | Tradjenta | none listed | $16.80 per tablet 5 mg tablet | No | No current entry | 0 |
| Empagliflozin and linagliptin | Glyxambi | none listed | $11.24 per tablet 10 mg-5 mg tablet | No | No current entry | 1 |
| Ertugliflozin and sitagliptin | Steglujan | none listed | $17.59 per tablet 15-100 mg tablet | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price