FDA pharmacologic class
Aldosterone antagonists
2 medicines are in FDA's class of aldosterone antagonists (aldosterone antagonists): spironolactone (Aldactone) and eplerenone (Inspra); 1 combination product also contains one. All 3 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is spironolactone 25 mg tablet at $0.0426 per tablet (NADAC).
Which medicines are aldosterone antagonists?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Spironolactone | Aldactone, Carospir | 38 labelers | $0.0426 per tablet 25 mg tablet | No | A presentation being discontinued | 6 |
| Eplerenone | Inspra | 9 labelers | $0.308 per tablet 25 mg tablet | No | No current entry | 0 |
| Hydrochlorothiazide and spironolactone | none listed | 6 labelers | $0.483 per tablet 25-25 tablet | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price