Alternatives to semaglutide
3 same-class SPL records vs semaglutide - uses, FAERS reaction fields, and OTC/Rx flags from public FDA sources.
Brand: Ozempic, Wegovy, Rybelsus
How to read a high-report FAERS peer set
semaglutide ranks in the upper FAERS-volume third of the corpus (#102 of 524); 3 same-class peers are listed for field comparison only. Labeled indication field for semaglutide: Ozempic is used to improve blood sugar control in adults with type 2 diabetes, along with diet and exercise.
Top FAERS reaction fields for semaglutide total 48,346 reports across 10 reactions, set beside dulaglutide, exenatide, liraglutide. Counts are exposure-weighted submissions, not per-patient risk.
About semaglutide
Ozempic is a medicine that helps lower blood sugar in adults with type 2 diabetes. It can also lower the risk of heart problems in adults with both type 2 diabetes and heart disease.
Used for: Ozempic is used to improve blood sugar control in adults with type 2 diabetes, along with diet and exercise. It can also reduce the risk of major heart problems like heart attack, stroke, or death in adults who have both type 2 diabetes and heart disease. Ozempic has not been studied in patients with a history of pancreatitis, so other diabetes medicines may be better for you.
3 GLP-1 Receptor Agonist peers (wide set)
dulaglutide
RxTrulicity
Trulicity helps adults and children 10 years and older manage their type 2 diabetes. It works along with diet and exercise to improve blood sugar control. Trulicity can also reduce the risk of major heart problems like heart attack, stroke, or death in adults with type 2 diabetes who also have heart disease or risk factors for it.
exenatide
RxByetta, Bydureon
Byetta helps adults with type 2 diabetes manage their blood sugar levels. It should be used with a healthy diet and regular exercise. This medicine helps to keep your blood sugar in a normal range.
liraglutide
RxVictoza, Saxenda
Liraglutide helps manage blood sugar levels in people with type 2 diabetes. You should use it along with a healthy diet and regular exercise. It is for adults and children aged 10 and older.
semaglutide vs dulaglutide & exenatide · FAERS reaction fields
FAERS top-reaction field "Constipation" shows the widest count spread between semaglutide and dulaglutide, exenatide, liraglutide in this extract (2,309-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | semaglutide | dulaglutide | exenatide | liraglutide |
|---|---|---|---|---|
| Nausea | 10,666 | 9,986 | 12,040 | 7,005 |
| Vomiting | 6,913 | 5,413 | 4,345 | 3,364 |
| Diarrhoea | 6,093 | 5,737 | 2,742 | 3,263 |
| Decreased Appetite | 4,428 | 3,153 | 5,643 | 2,066 |
| Constipation | 4,344 | 2,035 | - | 1,492 |
| Weight Decreased | 3,931 | 3,349 | 12,125 | 2,076 |
| Fatigue | 3,312 | 2,409 | 1,759 | 1,635 |
| Headache | 3,156 | - | 2,086 | 1,988 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
semaglutide FAERS volume vs class peers
FAERS volume band
semaglutide is FAERS corpus rank #102 of 524 (high volume tercile). Top-reaction field total: 48,346.
Frequently Asked Questions
Where does semaglutide sit in FAERS report volume vs GLP-1 Receptor Agonist peers? ▼
Registry note: FAERS counts are voluntary reports and do not establish causation or risk rates. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for semaglutide: see also the generic vs brand label guide when reading Ozempic SPL strings.
Read our methodology - how this data is sourced, computed, and verified.