Medicines labeled for the same conditions
Alternatives to prochlorperazine
11 other medicines are given the same way (oral) and in the same FDA class as prochlorperazine or labeled mainly for the same use (nausea and vomiting); 4 are in its class, phenothiazines: chlorpromazine, perphenazine, trifluoperazine and amitriptyline and perphenazine; the others include 2 antiemetics, 1 serotonin-3 receptor antagonist and 1 substance p/neurokinin-1 receptor antagonist (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.161 per perphenazine 4 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as prochlorperazine?
Nausea and vomiting lists all 16 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Prochlorperazinephenothiazine | this medicine | 29 labelers | $0.162 per tablet 10 mg tablet | Yes | No current entry |
| Chlorpromazinephenothiazine · same class | Schizophrenia, Nausea and vomiting | 22 labelers | $0.552 per tablet 100 mg tablet | Yes | No current entry |
| Perphenazinephenothiazine · same class | Schizophrenia, Nausea and vomiting | 16 labelers | $0.161 per tablet 4 mg tablet | Yes | No current entry |
| Trifluoperazinephenothiazine · same class | Anxiety, Schizophrenia | 6 labelers | $0.579 per tablet 2 mg tablet | Yes | No current entry |
| Amitriptyline and perphenazinetricyclic antidepressant · same class | Anxiety | 1 labeler | n/a | Yes | No current entry |
| Ondansetronserotonin-3 receptor antagonist | Nausea and vomiting | 60 labelers | $0.0582 per tablet 4 mg tablet | No | No current entry |
| Meclizineantiemetic | Nausea and vomiting | 24 labelers | $0.0442 per tablet 12.5 mg tablet | No | No current entry |
| Dimenhydrinate | Nausea and vomiting | none listed | $0.0575 per tablet 50 mg tablet | No | No current entry |
| Aprepitantsubstance p/neurokinin-1 receptor antagonist | Nausea and vomiting | 5 labelers | $46.42 per capsule 40 mg capsule | No | A presentation being discontinued |
| Doxylamine and pyridoxinevitamin b6 analog | Nausea and vomiting | 4 labelers | $1.09 per unit 10-10 mg | No | No current entry |
| Trimethobenzamideantiemetic | Nausea and vomiting | 4 labelers | n/a | No | No current entry |
| Tradipitant | Nausea and vomiting | none listed | n/a | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Prochlorperazine: the full record
- label, generics, price, shortages, recalls
- Chlorpromazine vs prochlorperazine
- two records side by side
- Ondansetron vs prochlorperazine
- two records side by side
- Prochlorperazine vs meclizine
- two records side by side
- Dimenhydrinate vs prochlorperazine
- two records side by side