Alternatives to palonosetron
FDA shortage status is active for palonosetron; 2 same-class SPL records are listed below for registry comparison only.
Brand: Aloxi
palonosetron class peers while FDA lists an active shortage
palonosetron (Aloxi) is on an FDA shortage listing while 2 other 5-HT3 Receptor Antagonist (Antiemetic) SPL records remain in this registry peer set (class inventory 3). Labeled indication field for palonosetron: Palonosetron is used to prevent nausea and vomiting caused by cancer chemotherapy.
Top FAERS reaction fields for palonosetron total 2,414 reports across 10 reactions, set beside granisetron, ondansetron. Counts are exposure-weighted submissions, not per-patient risk.
About palonosetron
Palonosetron is a medicine that helps prevent nausea and vomiting. It is often used before, during, and after chemotherapy or surgery.
Used for: Palonosetron is used to prevent nausea and vomiting caused by cancer chemotherapy. It can prevent these side effects from both the first treatment and any repeat treatments. Palonosetron is also used to prevent nausea and vomiting after surgery.
2 5-HT3 Receptor Antagonist (Antiemetic) peers (wide set)
granisetron
RxKytril
Granisetron is used to prevent nausea and vomiting. It is for people receiving cancer therapy that causes vomiting. This includes high doses of cisplatin, radiation, total body irradiation, and fractionated abdominal radiation.
ondansetron
RxZofran
This medicine is used to prevent nausea and vomiting. It can help if you are getting chemotherapy for cancer. It also helps with nausea and vomiting after surgery or radiation.
palonosetron vs granisetron & ondansetron · FAERS reaction fields
FAERS top-reaction field "Nausea" shows the widest count spread between palonosetron and granisetron, ondansetron in this extract (11,155-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | palonosetron | granisetron | ondansetron |
|---|---|---|---|
| Nausea | 399 | 1,305 | 11,554 |
| Fatigue | 249 | 549 | 8,199 |
| Febrile Neutropenia | 249 | 718 | 4,495 |
| Diarrhoea | 246 | 709 | 7,791 |
| Vomiting | 246 | 754 | 7,326 |
| Neutropenia | 245 | 474 | - |
| Alopecia | 223 | - | - |
| Dyspnoea | 194 | 592 | 4,707 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
palonosetron shortage vs 5-HT3 Receptor Antagonist (Antiemetic) peer index
Shortage status
FDA shortage listing is active for palonosetron (status: To Be Discontinued). Peer rows remain a registry index, not a switch guide.
Frequently Asked Questions
Does FDA list a shortage for palonosetron while peers remain indexed? ▼
Registry note: Shortage listings and peer indexes are for registry orientation only. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for palonosetron: see also the generic vs brand label guide when reading Aloxi SPL strings.
Read our methodology - how this data is sourced, computed, and verified.