Alternatives to omeprazole
FDA shortage status is active for omeprazole; 5 same-class SPL records are listed below for registry comparison only.
Brand: Prilosec
omeprazole class peers while FDA lists an active shortage
omeprazole (Prilosec) is on an FDA shortage listing while 5 other Proton Pump Inhibitor (PPI) SPL records remain in this registry peer set (class inventory 6). Labeled indication field for omeprazole: This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week.
Top FAERS reaction fields for omeprazole total 155,765 reports across 10 reactions, set beside dexlansoprazole, esomeprazole, lansoprazole. Counts are exposure-weighted submissions, not per-patient risk.
About omeprazole
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Used for: This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.
5 Proton Pump Inhibitor (PPI) peers (wide set)
dexlansoprazole
RxDexilant
This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach). It can also help with heartburn caused by acid reflux. Dexlansoprazole can also treat heartburn from GERD, a condition where stomach acid flows back into your esophagus.
esomeprazole
OTCNexium
This medicine treats frequent heartburn. Frequent heartburn means you have heartburn 2 or more days a week. This medicine is not for immediate relief of heartburn. It may take 1 to 4 days to work fully.
lansoprazole
OTCPrevacid
Lansoprazole can treat several conditions caused by too much stomach acid. It can heal duodenal and gastric ulcers. It also treats heartburn (GERD) and a damaged esophagus (erosive esophagitis).
pantoprazole
RxProtonix
This medicine treats gastroesophageal reflux disease (GERD) and erosive esophagitis (EE) in adults, for up to 10 days. GERD is when stomach acid flows back into your esophagus, causing heartburn. It also treats conditions where your stomach makes too much acid, like Zollinger-Ellison (ZE) Syndrome.
rabeprazole
RxAciphex
This medicine can treat several conditions caused by too much stomach acid. It can heal damage to your esophagus from acid reflux (GERD). It also treats heartburn, stomach ulcers, and conditions like Zollinger-Ellison syndrome where the body makes too much acid. Rabeprazole can also be used with antibiotics to get rid of a bacteria called H. pylori that can cause ulcers.
omeprazole vs dexlansoprazole & esomeprazole · FAERS reaction fields
FAERS top-reaction field "Fatigue" shows the widest count spread between omeprazole and dexlansoprazole, esomeprazole, lansoprazole in this extract (12,268-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | omeprazole | dexlansoprazole | esomeprazole | lansoprazole |
|---|---|---|---|---|
| Fatigue | 19,901 | 2,337 | 3,528 | 7,633 |
| Nausea | 19,842 | 2,138 | 4,004 | 8,964 |
| Diarrhoea | 19,627 | 1,947 | 3,869 | 8,752 |
| Dyspnoea | 16,336 | 1,542 | 3,268 | 7,945 |
| Headache | 14,629 | 1,902 | 3,509 | 6,742 |
| Pain | 13,759 | 1,902 | 2,752 | 6,733 |
| Chronic Kidney Disease | 13,547 | 16,100 | 5,020 | 32,775 |
| Vomiting | 13,263 | - | 2,692 | 7,064 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
omeprazole shortage vs Proton Pump Inhibitor (PPI) peer index
Shortage status
FDA shortage listing is active for omeprazole (status: To Be Discontinued). Peer rows remain a registry index, not a switch guide.
Frequently Asked Questions
Does FDA list a shortage for omeprazole while peers remain indexed? ▼
Registry note: Shortage listings and peer indexes are for registry orientation only. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for omeprazole: see also the generic vs brand label guide when reading Prilosec SPL strings.
Read our methodology - how this data is sourced, computed, and verified.