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Prescription medication · Rho Kinase Inhibitor / PGA Combination

netarsudil/latanoprost

Also sold as Rocklatan. Rocklatan is used to lower high pressure in your eyes.

Data updated 2026-05-15

1,191
FDA reports
1
InteractionFew interactions
$131.84
Brand price (NADAC)

What the data shows

netarsudil/latanoprost (Rocklatan) is a prescription Rho Kinase Inhibitor / PGA Combination, with 1,191 FDA adverse-event reports on file, with 1 documented drug interaction.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

netarsudil/latanoprost (Rocklatan) is a prescription Rho Kinase Inhibitor / PGA Combination. Rocklatan is used to lower high pressure in your eyes.

Rocklatan is an eye drop medicine that lowers pressure inside the eye. It is used for people with open-angle glaucoma or ocular hypertension.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$131.84/unit

Generic Available

No

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

View Alternatives → Compare with Another Drug →

What it does

Rocklatan is used to lower high pressure in your eyes.

Common side effects

Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%)

Key warnings

Rocklatan can cause changes in eye color, eyelid, and eyelashes.

The sections below are summarized in plain English from netarsudil/latanoprost's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Rocklatan contains two medicines that work together. One medicine helps to relax eye tissues to allow fluid to drain better. The other medicine helps to reduce the amount of fluid your eye makes. This combination lowers the pressure in your eye.

How to Take It

Use one drop of Rocklatan in the affected eye(s) once a day in the evening. Try to use the drops at the same time each evening. If you miss a dose, just continue with your next dose the following evening. Do not use Rocklatan more than once a day. If you use other eye drops, wait at least 5 minutes before using them.

This is a plain-language summary of netarsudil/latanoprost's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.

Pregnancy & Breastfeeding

It is not known if Rocklatan will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Rocklatan passes into breast milk. Discuss with your doctor if you are breastfeeding.

This is a plain-language summary of netarsudil/latanoprost's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.

Missed Dose

If you miss a dose of Rocklatan, continue with your next dose in the evening. Do not use a double dose to make up for the missed dose.

This is a plain-language summary of netarsudil/latanoprost's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.

Storage

Keep Rocklatan protected from light and refrigerated until opened. After opening, it can be stored at room temperature for up to 6 weeks, or refrigerated until the expiration date.

Side Effects (from patient reports)

Based on 1,191 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for netarsudil/latanoprost, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

Rocklatan can cause changes in eye color, eyelid, and eyelashes. The color change in the iris (colored part of the eye) may be permanent. Eyelash changes, like increased length and thickness, are usually reversible when you stop using Rocklatan. This medicine may also cause swelling in the cornea, especially if you have existing cornea problems or have had eye surgery. Tell your doctor if you have eye pain or vision changes.

Known Drug Interactions

moderate latanoprost

The combined use of two or more prostaglandins or prostaglandin analogs including latanoprost ophthalmic solution 0.005% is not recommended.

Mechanism: Both drugs are in the same family and work the same way. Using more than one at a time can actually make them less effective at lowering eye pressure.

What to do: You should not use these two eye drops together. Your doctor will likely have you use just one of these medications.

This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.

Common Questions

Can I use Rocklatan more than once a day to lower my eye pressure faster?
No, do not use Rocklatan more than once a day. Using it more often may make it less effective.
What should I do if I wear contact lenses?
Remove your contact lenses before using Rocklatan. You can put them back in 15 minutes after using the drops.
How long does it take for Rocklatan to start working?
Rocklatan starts working soon after you use it, but it may take a few weeks to see the full effect on your eye pressure.
Can I use Rocklatan with other eye drops?
Yes, you can use Rocklatan with other eye drops, but wait at least 5 minutes between using each medicine.
What if I accidentally get Rocklatan in my mouth?
Rinse your mouth with water. If you feel unwell, contact your doctor.
Can Rocklatan cause my eyelashes to grow longer?
Yes, Rocklatan can cause your eyelashes to grow longer, thicker, and darker. These changes are usually reversible when you stop using the medicine.
Will Rocklatan change my eye color?
Yes, Rocklatan can cause the colored part of your eye (iris) to become more brown. This change may be permanent.
What should I do if I experience eye pain or vision changes while using Rocklatan?
Tell your doctor right away if you have eye pain or vision changes.
Can I drive or operate machinery after using Rocklatan?
Rocklatan may cause blurred vision temporarily. Do not drive or operate machinery until your vision is clear.
How long can I use Rocklatan after opening the bottle?
You can use Rocklatan for up to 6 weeks after opening the bottle if stored at room temperature, or until the expiration date if refrigerated.
What are the common side effects of netarsudil/latanoprost?
The most commonly reported side effects of netarsudil/latanoprost include Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%), Bleeding in the eye (11%). Based on 1,191 FDA adverse event reports. Always consult your healthcare provider about potential side effects.
Does netarsudil/latanoprost interact with other medications?
Yes, netarsudil/latanoprost has 1 known drug interactions. Notable interactions include latanoprost. Always inform your doctor about all medications you are taking.
What drug class is netarsudil/latanoprost?
netarsudil/latanoprost belongs to the Rho Kinase Inhibitor / PGA Combination drug class. It requires a prescription (Rx). Rocklatan is used to lower high pressure in your eyes.
Is netarsudil/latanoprost safe during pregnancy?
It is not known if Rocklatan will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

Related Medications in Rho Kinase Inhibitor / PGA Combination

Other drugs grouped near netarsudil/latanoprost - same-class peers and common alternatives.

aflibercept

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artificial tears

Refresh, Systane

Artificial tears are eye drops that lubricate your eyes.

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bevacizumab (ophthalmic)

Avastin

Avastin is a medicine that blocks a protein called vascular endothelial growth factor (VEGF).

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bimatoprost

Lumigan

Bimatoprost eye drops help lower pressure in the eye.

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brimonidine ophthalmic

Alphagan P

Alphagan P eye drops help lower pressure in the eye.

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What the FDA Data Shows for netarsudil/latanoprost

The FDA label for netarsudil/latanoprost (sold under brand names such as Rocklatan) classifies it as a prescription-only medication in the Rho Kinase Inhibitor / PGA Combination class. Rocklatan is used to lower high pressure in your eyes. Official labeling lists 4 commonly reported side effects, including Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%).

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,191 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.

Last updated: January 20, 2026

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.

All federal data sources used on this page