Medicines labeled for the same conditions
Alternatives to glimepiride and pioglitazone
29 other medicines are given the same way (oral) and in the same FDA class as glimepiride and pioglitazone or labeled mainly for the same use (type 2 diabetes); 4 are in its class, peroxisome proliferator receptor gamma agonists: glipizide, glyburide, glyburide and metformin and glipizide and metformin; the others include 9 dipeptidyl peptidase 4 inhibitors, 7 sodium-glucose cotransporter 2 inhibitors and 2 biguanides (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0339 per glipizide 5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as glimepiride and pioglitazone?
The first 24 of the 29, the same class first. Type 2 diabetes lists all 52 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Glimepiride and pioglitazoneperoxisome proliferator receptor gamma agonist | this medicine | none listed | $10.52 per unit 30-4 | Yes | No current entry |
| Glipizidesulfonylurea · same class | Type 2 diabetes | 31 labelers | $0.0339 per tablet 5 mg tablet | No | No current entry |
| Glyburidesulfonylurea · same class | Type 2 diabetes | 16 labelers | $0.0643 per tablet 5 mg tablet | No | A presentation being discontinued |
| Glyburide and metforminsulfonylurea · same class | Type 2 diabetes | 11 labelers | $0.171 per unit 2.5-500 mg | Yes | No current entry |
| Glipizide and metforminsulfonylurea · same class | Type 2 diabetes | 9 labelers | $0.242 per unit 2.5-250 mg | No | No current entry |
| Metforminbiguanide | Type 2 diabetes | 83 labelers | $0.0145 per tablet 500 mg tablet | Yes | No current entry |
| Dapagliflozin and metforminsodium-glucose cotransporter 2 inhibitor | Type 2 diabetes | 8 labelers | $0.720 per tablet 10-1,000 mg tablet | Yes | No current entry |
| Metformin and sitagliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | 4 labelers | $1.76 per tablet 50 mg-1,000 mg tablet | Yes | No current entry |
| Sitagliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | 4 labelers | $3.77 per tablet 100 mg tablet | No | No current entry |
| Repaglinideglinide | Type 2 diabetes | 7 labelers | $0.0987 per tablet 1 mg tablet | No | No current entry |
| Nateglinideglinide | Type 2 diabetes | 9 labelers | $0.179 per tablet 60 mg tablet | No | No current entry |
| Acarbosealpha-glucosidase inhibitor | Type 2 diabetes | 6 labelers | $0.274 per tablet 100 mg tablet | No | No current entry |
| Alogliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | none listed | $4.96 per tablet 12.5 mg tablet | No | No current entry |
| SemaglutideGLP-1 receptor agonist | Type 2 diabetes | none listed | $33.13 per tablet 1.5 mg tablet | Yes | A presentation being discontinued |
| Canagliflozin and metforminsodium-glucose cotransporter 2 inhibitor | Type 2 diabetes | none listed | $9.58 per tablet 150-1,000 mg tablet | Yes | No current entry |
| Empagliflozin and metforminsodium-glucose cotransporter 2 inhibitor | Type 2 diabetes | none listed | $5.60 per tablet 12.5-1,000 mg tablet | Yes | No current entry |
| Linagliptin and metformindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | 1 labeler | $8.44 per tablet 2.5 mg-1,000 mg tablet | Yes | No current entry |
| Metformin and saxagliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | 2 labelers | $9.65 per tablet 5-1,000 mg tablet | Yes | No current entry |
| Miglitolalpha-glucosidase inhibitor | Type 2 diabetes | 2 labelers | n/a | No | No current entry |
| Saxagliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | 3 labelers | $1.04 per tablet 5 mg tablet | No | No current entry |
| Alogliptin and metformindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | none listed | $2.46 per unit 12.5-1000 | Yes | No current entry |
| Empagliflozin and linagliptin and metforminsodium-glucose cotransporter 2 inhibitor | Type 2 diabetes | none listed | $11.28 per tablet 10-5-1,000 mg tablet | Yes | No current entry |
| Ertugliflozin and metforminbiguanide | Type 2 diabetes | none listed | $5.76 per tablet 2.5-1,000 mg tablet | Yes | No current entry |
| Bexagliflozinsodium-glucose cotransporter 2 inhibitor | Type 2 diabetes | none listed | n/a | No | No current entry |
| Linagliptindipeptidyl peptidase 4 inhibitor | Type 2 diabetes | none listed | $16.80 per tablet 5 mg tablet | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Glimepiride and pioglitazone: the full record
- label, generics, price, shortages, recalls