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Prescription medication · NS3/4A/NS5A Inhibitor (HCV)

glecaprevir/pibrentasvir

Also sold as Mavyret. Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6.

Data updated 2026-05-15

8,300
FDA reports
38
InteractionsSeveral interactions
$152.83
Brand price (NADAC)

What the data shows

glecaprevir/pibrentasvir (Mavyret) is a prescription NS3/4A/NS5A Inhibitor (HCV), with 8,300 FDA adverse-event reports on file, with 38 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

glecaprevir/pibrentasvir (Mavyret) is a prescription NS3/4A/NS5A Inhibitor (HCV). Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6.

Mavyret is a medicine used to treat hepatitis C (HCV) in adults and children 3 years and older. It contains two drugs, glecaprevir and pibrentasvir, that work together to stop the virus from multiplying.

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Drug Pricing (NADAC)

Brand Price

$152.83/unit

Generic Available

No

ABBVIE

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6.

Common side effects

Headache, Feeling tired, Nausea

Key warnings

Mavyret can cause hepatitis B to become active again if you have had it in the past.

The sections below are summarized in plain English from glecaprevir/pibrentasvir's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Mavyret contains glecaprevir and pibrentasvir. Glecaprevir blocks a protein called NS3/4A protease that the virus needs to multiply. Pibrentasvir blocks a protein called NS5A, also needed for the virus to multiply. By blocking these proteins, Mavyret stops the hepatitis C virus from spreading in your body.

How to Take It

Take Mavyret tablets or oral pellets once a day, at the same time each day. Always take Mavyret with food. For adults and children 12 years and older, the usual dose is three tablets daily. For children 3-12 years old, the dose is based on weight. Your doctor will tell you how long to take Mavyret, usually for 8-16 weeks.

This is a plain-language summary of glecaprevir/pibrentasvir's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.

Pregnancy & Breastfeeding

It is not known if Mavyret will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Mavyret passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking Mavyret.

This is a plain-language summary of glecaprevir/pibrentasvir's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.

Missed Dose

If you miss a dose of Mavyret, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

This is a plain-language summary of glecaprevir/pibrentasvir's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.

Storage

Store Mavyret tablets and oral pellets at or below 86°F (30°C).

Side Effects (from patient reports)

Based on 8,300 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for glecaprevir/pibrentasvir, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

Mavyret can cause hepatitis B to become active again if you have had it in the past. This can cause serious liver problems, including liver failure and death. Your doctor will test you for hepatitis B before you start Mavyret. They will also monitor you during and after treatment.

Known Drug Interactions

major rifampin

Antimycobacterials: Rifampin ↓ glecaprevir ↓ pibrentasvir Coadministration is contraindicated because of potential loss of therapeutic effect [see Contraindications ( 4 ) ] .

Mechanism: Rifampin lowers the levels of the hepatitis C medicine in your body. This makes the treatment less effective and may prevent it from curing the infection.

What to do: Do not take these medications together because the hepatitis C treatment will not work correctly.

major rosuvastatin

Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.

Mechanism: These drugs can cause rosuvastatin levels to rise in your body, which may increase the risk of side effects.

What to do: Your doctor should start you on a low 5 mg dose of rosuvastatin and keep the total daily dose at 10 mg or less.

major rosuvastatin/ezetimibe

Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.

Mechanism: These hepatitis C drugs block the pathways your body uses to remove rosuvastatin, leading to higher levels of the statin in your blood. This can increase your risk for serious side effects.

What to do: Your doctor should start your rosuvastatin at 5 mg daily and keep the dose at or below 10 mg per day.

moderate cyclosporine

Immunosuppressants: Cyclosporine ↑ glecaprevir ↑ pibrentasvir MAVYRET is not recommended for use in patients requiring stable cyclosporine doses > 100 mg per day.

Mechanism: Cyclosporine causes the levels of glecaprevir and pibrentasvir to increase in your body. This happens because cyclosporine interferes with how the body processes these medications.

What to do: This combination is not recommended if you take more than 100 mg of cyclosporine per day. Your doctor may need to review your current medications before starting this treatment.

moderate darunavir

glecaprevir/pibrentasvir ↑ glecaprevir ↑ pibrentasvir Co-administration of darunavir/ritonavir with glecaprevir/pibrentasvir is not recommended.

Mechanism: Darunavir increases the amount of glecaprevir and pibrentasvir that stays in your body. This can make the hepatitis C medication more likely to cause side effects.

What to do: This combination is not recommended, so you should ask your doctor for a different treatment option.

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This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.

Common Questions

How long will I need to take Mavyret?
The usual treatment time is 8 to 16 weeks, depending on your specific situation.
Can I take Mavyret if I have kidney problems?
Yes, you can usually take Mavyret if you have kidney problems. Follow the dosage your doctor prescribes.
Can I take Mavyret if I have HIV?
Yes, you can usually take Mavyret if you have HIV. Follow the dosage your doctor prescribes.
What should I do if I vomit after taking Mavyret?
If you vomit shortly after taking Mavyret, talk to your doctor. You may need to take another dose.
Can I drink alcohol while taking Mavyret?
Talk to your doctor about drinking alcohol while taking Mavyret. They can advise you based on your liver health.
Will Mavyret interact with other medications I am taking?
Mavyret can interact with other medications. Tell your doctor about all the medicines you take, including over-the-counter drugs and supplements.
How will I know if Mavyret is working?
Your doctor will do blood tests to check the amount of hepatitis C virus in your blood. This will show if the medicine is working.
What if I have side effects from Mavyret?
Tell your doctor about any side effects you have while taking Mavyret. They can help you manage them.
Can children take Mavyret?
Yes, Mavyret can be used in children 3 years and older.
Is there a generic version of Mavyret?
No, there is currently no generic version of Mavyret available.
What are the common side effects of glecaprevir/pibrentasvir?
The most commonly reported side effects of glecaprevir/pibrentasvir include Headache, Feeling tired, Nausea. Based on 8,300 FDA adverse event reports. Always consult your healthcare provider about potential side effects.
Does glecaprevir/pibrentasvir interact with other medications?
Yes, glecaprevir/pibrentasvir has 38 known drug interactions. Notable interactions include rifampin, rosuvastatin, rosuvastatin/ezetimibe. Always inform your doctor about all medications you are taking.
What drug class is glecaprevir/pibrentasvir?
glecaprevir/pibrentasvir belongs to the NS3/4A/NS5A Inhibitor (HCV) drug class. It requires a prescription (Rx). Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6.
Is glecaprevir/pibrentasvir safe during pregnancy?
It is not known if Mavyret will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

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What the FDA Data Shows for glecaprevir/pibrentasvir

The FDA label for glecaprevir/pibrentasvir (sold under brand names such as Mavyret) classifies it as a prescription-only medication in the NS3/4A/NS5A Inhibitor (HCV) class. Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6. Official labeling lists 3 commonly reported side effects, including Headache, Feeling tired, Nausea.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 8,300 voluntary reports. The database also lists 38 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.

Last updated: June 10, 2025

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.

All federal data sources used on this page