Medicines labeled for the same conditions
Alternatives to amitriptyline and perphenazine
13 other medicines are given the same way (oral) and in the same FDA class as amitriptyline and perphenazine or labeled mainly for the same use (anxiety); 4 are in its class, tricyclic antidepressants: doxepin, prochlorperazine, trifluoperazine and amoxapine; the others include 6 benzodiazepines and 1 antihistamine (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0779 per doxepin 10 mg capsule (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as amitriptyline and perphenazine?
Anxiety lists all 22 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Amitriptyline and perphenazinetricyclic antidepressant | this medicine | 1 labeler | n/a | Yes | No current entry |
| Doxepintricyclic antidepressant · same class | Anxiety | 48 labelers | $0.0779 per capsule 10 mg capsule | Yes | No current entry |
| Prochlorperazinephenothiazine · same class | Anxiety | 29 labelers | $0.162 per tablet 10 mg tablet | Yes | No current entry |
| Trifluoperazinephenothiazine · same class | Anxiety | 6 labelers | $0.579 per tablet 2 mg tablet | Yes | No current entry |
| Amoxapinetricyclic antidepressant · same class | Anxiety | 2 labelers | n/a | Yes | No current entry |
| Buspirone | Anxiety | 49 labelers | $0.043 per tablet 15 mg tablet | No | No current entry |
| Hydroxyzineantihistamine | Anxiety | 59 labelers | $0.0326 per tablet 25 mg tablet | No | No current entry |
| Alprazolambenzodiazepine | Anxiety | 30 labelers | $0.0236 per tablet 0.25 mg tablet | Yes | No current entry |
| Lorazepambenzodiazepine | Anxiety | 33 labelers | $0.0344 per tablet 0.5 mg tablet | Yes | In shortage |
| Diazepambenzodiazepine | Anxiety | 32 labelers | $0.0283 per tablet 10 mg tablet | Yes | No current entry |
| Chlordiazepoxidebenzodiazepine | Anxiety | 15 labelers | $0.158 per capsule 25 mg capsule | Yes | No current entry |
| Clorazepatebenzodiazepine | Anxiety | 8 labelers | $0.524 per tablet 3.75 mg tablet | Yes | No current entry |
| Oxazepambenzodiazepine | Anxiety | 6 labelers | $0.725 per capsule 10 mg capsule | Yes | No current entry |
| Meprobamate | Anxiety | 3 labelers | $5.89 per tablet 400 mg tablet | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Amitriptyline and perphenazine: the full record
- label, generics, price, shortages, recalls