Medicines labeled for the same conditions
Alternatives to acetaminophen, butalbital, caffeine and codeine
27 other medicines are given the same way (oral) and in the same FDA class as acetaminophen, butalbital, caffeine and codeine or labeled mainly for the same use (pain); 12 are in its class, barbiturates: oxycodone, tramadol, morphine, hydromorphone and 8 more; the others include 5 nonsteroidal anti-inflammatory drugs, 1 cyclooxygenase inhibitor and 1 cholinergic muscarinic antagonist (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0248 per tramadol HCl 50 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as acetaminophen, butalbital, caffeine and codeine?
The first 24 of the 27, the same class first. Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Acetaminophen, butalbital, caffeine and codeinebarbiturate | this medicine | 5 labelers | $0.798 per capsule 50-325-40-30 mg capsule | Yes | No current entry |
| Oxycodoneopioid agonist · same class | Pain | 34 labelers | $0.0884 per tablet 5 mg tablet | Yes | No current entry |
| Tramadolopioid agonist · same class | Pain | 40 labelers | $0.0248 per tablet 50 mg tablet | Yes | No current entry |
| Morphineopioid agonist · same class | Pain | 17 labelers | $0.226 per tablet 15 mg tablet | Yes | In shortage |
| Hydromorphoneopioid agonist · same class | Pain | 11 labelers | $0.219 per tablet 4 mg tablet | Yes | In shortage |
| Methadoneopioid agonist · same class | Pain | 17 labelers | $0.177 per tablet 10 mg tablet | Yes | No current entry |
| Oxymorphoneopioid agonist · same class | Pain | 9 labelers | n/a | Yes | No current entry |
| Tapentadolopioid agonist · same class | Pain | 4 labelers | $14.48 per tablet 100 mg tablet | Yes | No current entry |
| Hydrocodoneopioid agonist · same class | Pain | 1 labeler | $7.95 per capsule 15 mg capsule | Yes | No current entry |
| Levorphanolopioid agonist · same class | Pain | 7 labelers | $10.65 per tablet 2 mg tablet | Yes | No current entry |
| Hydrocodone and ibuprofenopioid agonist · same class | Pain | 2 labelers | $0.487 per unit 7.5-200 | Yes | No current entry |
| Meperidineopioid agonist · same class | Pain | 3 labelers | $0.157 per mL 50 mg/5 mL solution | Yes | Listed; available |
| Aspirin and oxycodoneplatelet aggregation inhibitor · same class | Pain | 1 labeler | n/a | Yes | No current entry |
| Aspirin | Pain | none listed | $0.0142 per tablet 81 mg tablet | No | A presentation being discontinued |
| Diclofenacnonsteroidal anti-inflammatory drug | Pain | 67 labelers | $0.0619 per tablet 75 mg tablet | Yes | A presentation being discontinued |
| Phenazopyridine | Pain | none listed | $0.154 per tablet 100 mg tablet | No | No current entry |
| Etodolacnonsteroidal anti-inflammatory drug | Pain | 30 labelers | $0.262 per tablet 400 mg tablet | Yes | No current entry |
| Ketorolaccyclooxygenase inhibitor | Pain | 33 labelers | $0.164 per tablet 10 mg tablet | Yes | In shortage |
| Phenol | Pain | none listed | $0.0124 per mL 1.4% spray | No | No current entry |
| Benzocaine | Pain | none listed | n/a | No | No current entry |
| Levomenthol | Pain | none listed | n/a | No | No current entry |
| Fenoprofennonsteroidal anti-inflammatory drug | Pain | 6 labelers | n/a | Yes | No current entry |
| Diflunisalnonsteroidal anti-inflammatory drug | Pain | 6 labelers | $1.06 per tablet 500 mg tablet | Yes | No current entry |
| Mefenamic acidnonsteroidal anti-inflammatory drug | Pain | 6 labelers | $0.948 per capsule 250 mg capsule | Yes | No current entry |
| Flavoxatecholinergic muscarinic antagonist | Pain | 3 labelers | $0.389 per tablet 100 mg tablet | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Acetaminophen, butalbital, caffeine and codeine: the full record
- label, generics, price, shortages, recalls