FDA Drug Shortage Database
Bupivacaine (Exparel) shortage
The FDA Drug Shortage Database lists 8 of 35 bupivacaine presentations as limited or unavailable (updated October 2, 2026); the first entry was posted on February 20, 2018. 22 more presentations are on the list as available.
- Generic listed
- In shortage
- Boxed warning
Check it at the source: the FDA Drug Shortage Database.
Which strengths are short?
| Strength | Limited or unavailable now | Listed now, available | Resolved or discontinued |
|---|---|---|---|
| 0.75% injection | 1 | 1 | 0 |
| 2.5mg/1ml injection | 2 | 9 | 2 |
| 5mg/1ml injection | 2 | 8 | 2 |
| 7.5mg/1ml injection | 2 | 4 | 1 |
| 15mg/2ml injection | 1 | 0 | 0 |
Which presentations are listed?
Limited or unavailable now (8)
| Presentation | Company | Status and dates | Availability and reason given |
|---|---|---|---|
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-722-32) | Kindos Pharmaceuticals Co. Ltd. | Current posted February 20, 2018, updated May 5, 2026 | Limited Availability; Discontinuation of the manufacture of the drug |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-723-52) | Kindos Pharmaceuticals Co. Ltd. | Current posted February 20, 2018, updated May 5, 2026 | Limited Availability; Discontinuation of the manufacture of the drug |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-725-32) | Kindos Pharmaceuticals Co. Ltd. | Current posted February 20, 2018, updated May 5, 2026 | Limited Availability; Discontinuation of the manufacture of the drug |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-726-52) | Kindos Pharmaceuticals Co. Ltd. | Current posted February 20, 2018, updated May 5, 2026 | Limited Availability; Discontinuation of the manufacture of the drug |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 71288-728-32) | Kindos Pharmaceuticals Co. Ltd. | Current posted February 20, 2018, updated May 5, 2026 | Limited Availability; Discontinuation of the manufacture of the drug |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 73293-0002-2) | Huons Co., Ltd | Current posted February 20, 2018, updated July 30, 2026 | Unavailable; Demand increase for the drug |
| Bupivacaine Hydrochloride, Injection, Bupivacaine Spinal 15 mg/2 mL (7.5 mg/mL in 8.25% dextrose) (NDC 0409-3613-01) | Hospira, Inc., a Pfizer Company | Current posted February 20, 2018, updated September 22, 2026 | Limited Availability; Demand increase for the drug |
| Marcaine, Injection, 0.75% 15 mg/2 mL (7.5 mg/mL) in Dextrose 8.25% (NDC 0409-1761-10) | Hospira, Inc., a Pfizer Company | Current posted February 20, 2018, updated September 22, 2026 | Unavailable; Other |
Listed now, available (22)
| Presentation | Company | Status and dates | Availability and reason given |
|---|---|---|---|
| Bupivacaine Hydrochloride PRESERVATIVE FREE, Injection, 2.5 mg/1 mL 5mg / 1mL (NDC 72266-263-10) | ONESOURCE SPECIALTY PTE LTD | Current posted February 20, 2018, updated September 18, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-32) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-34) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-167-10) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-168-30) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-249-50) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-01) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-10) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-25) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 31722-276-32) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 31722-276-34) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-169-10) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-170-30) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-250-50) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-01) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-10) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-25) | Somerset Therapeutics, LLC | Current posted February 20, 2018, updated September 11, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 31722-277-32) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 31722-277-34) | Aspiro Pharma Limited | Current posted February 20, 2018, updated July 17, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 55150-171-10) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 55150-172-30) | Eugia US LLC | Current posted February 20, 2018, updated October 2, 2026 | Available |
| Marcaine, Injection, 0.75% 15 mg/2 mL (NDC 0409-1761-62) | Hospira, Inc., a Pfizer Company | Current posted February 20, 2018, updated September 22, 2026 | Available |
Resolved or discontinued (5)
| Presentation | Company | Status and dates | Availability and reason given |
|---|---|---|---|
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-722-32) | Kindos Pharmaceuticals Co. Ltd. | To Be Discontinued posted May 5, 2026, updated May 5, 2026 | not given |
| Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-723-52) | Kindos Pharmaceuticals Co. Ltd. | To Be Discontinued posted May 5, 2026, updated May 5, 2026 | not given |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-725-32) | Kindos Pharmaceuticals Co. Ltd. | To Be Discontinued posted May 5, 2026, updated May 5, 2026 | not given |
| Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-726-52) | Kindos Pharmaceuticals Co. Ltd. | To Be Discontinued posted May 5, 2026, updated May 5, 2026 | not given |
| Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 71288-728-32) | Kindos Pharmaceuticals Co. Ltd. | To Be Discontinued posted May 5, 2026, updated May 5, 2026 | not given |
Source: FDA Drug Shortage Database via openFDA, read October 8, 2026
What next?
- Every shortage now
- medicines by presentations in shortage