What the FDA labels say about taking them together
Rifampin and zaleplon
Zaleplon's FDA label of May 8, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name zaleplon.
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the zaleplon FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the rifampin label say about zaleplon?
Rifampin's label (effective February 11, 2026) does not name zaleplon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the zaleplon label say about rifampin?
Zaleplon label, drug interactionsDrugs That Induce CYP3A4 Rifampin CYP3A4 is ordinarily a minor metabolizing enzyme of zaleplon.
Source: FDA drug label (ZALEPLON), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set e092f3ca-bf44-4568-a72c-3fb2cf5b192b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Zaleplon | |
|---|---|---|
| Labeled for | n/a | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $0.141 per capsule 10 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once