What the FDA labels say about taking them together
Erythromycin and zaleplon
Zaleplon's FDA label of May 8, 2024 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name zaleplon. The zaleplon label: “Coadministration of single, oral doses of zaleplon with erythromycin, a strong, selective CYP3A4 inhibitor, produced a 34% increase in zaleplon’s maximal plasma concentrations and a 20% increase in the area under the …”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the zaleplon FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the erythromycin label say about zaleplon?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name zaleplon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the zaleplon label say about erythromycin?
Zaleplon label, drug interactionsCoadministration of single, oral doses of zaleplon with erythromycin (10 mg and 800 mg respectively), a strong, selective CYP3A4 inhibitor, produced a 34% increase in zaleplon’s maximal plasma concentrations and a 20% increase in the area under the plasma concentration-time curve.
Source: FDA drug label (ZALEPLON), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set e092f3ca-bf44-4568-a72c-3fb2cf5b192b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Zaleplon | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $0.141 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once