What the FDA labels say about taking them together
Cimetidine and zaleplon
Zaleplon's FDA label of May 8, 2024 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name zaleplon.
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the zaleplon FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the cimetidine label say about zaleplon?
Cimetidine's label (effective July 15, 2026) does not name zaleplon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the zaleplon label say about cimetidine?
Zaleplon label, drug interactionsDrugs That Inhibit Both Aldehyde Oxidase and CYP3A4 Cimetidine: Cimetidine inhibits both aldehyde oxidase ( in vitro ) and CYP3A4 ( in vitro and in vivo ), the primary and secondary enzymes, respectively, responsible for zaleplon metabolism.
Source: FDA drug label (ZALEPLON), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set e092f3ca-bf44-4568-a72c-3fb2cf5b192b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Zaleplon | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.141 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once