What the FDA labels say about taking them together
Methadone and vortioxetine
Vortioxetine's FDA label of March 5, 2025 names methadone in its drug interactions section; the methadone labels PlainMeds reads (4) do not name vortioxetine. The vortioxetine label: “The risk is increased with concomitant use of other serotonergic drugs and with drugs that impair metabolism of serotonin, i.e., MAOIs.”
Check it at the source: the methadone FDA label on DailyMed (effective December 8, 2025, Epic Pharma, LLC); the vortioxetine FDA label on DailyMed (effective March 5, 2025, Takeda Pharmaceuticals America, Inc.).
What does the methadone label say about vortioxetine?
Methadone's label (effective December 8, 2025) and its 3 other brand-application labels do not name vortioxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methadone Hydrochloride), Epic Pharma, LLC, effective December 8, 2025 (SPL set 6da7501b-b881-4bc7-891a-74214a00a3ac), via openFDA; the full label on DailyMed
What does the vortioxetine label say about methadone?
Vortioxetine label, drug interactions… with coadministration of TRINTELLIX (10 mg/day) and warfarin (1 mg/day to 10 mg/day), a highly protein bound drug, no significant change in INR was observed [see Drug Interactions (7.1), Clinical Pharmacology (12.3) ]. Immunoassays for Methadone False positive results in urine enzyme immunoassays for methadone have been reported in patients who have taken vortioxetine. An alternative analytical technique (e.g., chromatographic methods) should be considered to confirm positive methadone urine drug screen results.
Vortioxetine label, warnings and precautionsThe risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, meperidine, methadone, buspirone, amphetamines, and St. John's Wort) and with drugs that impair metabolism of serotonin, i.e., MAOIs [see Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Trintellix), Takeda Pharmaceuticals America, Inc., effective March 5, 2025 (SPL set 1a5b68e2-14d0-419d-9ec6-1ca97145e838), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methadone | Vortioxetine | |
|---|---|---|
| Labeled for | Pain, Opioid use disorder | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.177 per tablet 10 mg tablet | $17.20 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once